PMID- 23368946
OWN - NLM
STAT- MEDLINE
DCOM- 20140619
LR  - 20151119
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 84
IP  - 9
DP  - 2013 Sep
TI  - Increased levels of serum and gingival crevicular fluid monocyte chemoattractant 
      protein-1 in smokers with periodontitis.
PG  - e23-8
LID - 10.1902/jop.2013.120666 [doi]
AB  - BACKGROUND: Smoking alters the host response, including vascular function, 
      neutrophil/monocyte activities, adhesion molecule expression, antibody 
      production, and cytokine and inflammatory mediator release. Monocyte 
      chemoattractant protein-1 (MCP-1) is involved in the activation and recruitment 
      of inflammatory and immune cells to infected sites, thereby mediating a variety 
      of pathophysiologic conditions. Estimation of serum and gingival crevicular fluid 
      (GCF) MCP levels could be a reliable indicator of periodontal disease activity. 
      Hence, the objective of this study is to analyze the serum and GCF MCP-1 levels 
      of smokers and never-smokers with periodontitis and compare them with those in 
      periodontally healthy individuals. METHODS: A total of 90 participants (30 
      periodontally healthy individuals, 30 non-smoking individuals with periodontitis, 
      and 30 smokers with periodontitis) formed the study group. Serum and GCF samples 
      were collected, and MCP-1 levels were estimated using enzyme-linked immunosorbent 
      assay. RESULTS: Mean MCP-1 levels in serum and GCF were found to be highest in 
      smokers with periodontitis, followed by the periodontitis group, and then by the 
      healthy controls. The values were statistically significant (P <0.001). 
      CONCLUSIONS: It can be concluded that the high levels of both serum and GCF MCP-1 
      found in smokers could explain the severity of periodontitis in smokers. More 
      longitudinal, prospective studies will help to verify the observations of the 
      present study. Further research in this direction could reveal reliable markers 
      to forecast the progression of periodontitis in high-risk groups.
FAU - Anil, Sukumaran
AU  - Anil S
AD  - Department of Periodontics and Community Dentistry, College of Dentistry, King 
      Saud University, Riyadh, Saudi Arabia. anil@graduate.hku.hk
FAU - Preethanath, R S
AU  - Preethanath RS
FAU - Alasqah, Mohammed
AU  - Alasqah M
FAU - Mokeem, Sameer A
AU  - Mokeem SA
FAU - Anand, Pradeep S
AU  - Anand PS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130131
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis/blood
MH  - Chemokine CCL2/analysis/*blood
MH  - Disease Progression
MH  - Gingival Crevicular Fluid/*chemistry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Periodontal Attachment Loss/blood/metabolism
MH  - Periodontal Pocket/blood/metabolism
MH  - Periodontitis/*blood/classification/metabolism
MH  - Smoking/*blood/metabolism
EDAT- 2013/02/02 06:00
MHDA- 2014/06/20 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2014/06/20 06:00 [medline]
AID - 10.1902/jop.2013.120666 [doi]
PST - ppublish
SO  - J Periodontol. 2013 Sep;84(9):e23-8. doi: 10.1902/jop.2013.120666. Epub 2013 Jan 
      31.