PMID- 233692
OWN - NLM
STAT- MEDLINE
DCOM- 19830617
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 47
IP  - 6
DP  - 1978 Dec
TI  - Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia 
      versus typical primary hyperparathyroidism.
PG  - 1190-7
AB  - Three indices of circulating parathyroid hormone (PTH) activity were compared 
      between two groups: the first a group of 23 patients from three large kindreds 
      with autosomal dominant hypercalcemia without hypercalciuria [familial 
      hypocalciuric hypercalcemia (FHH)] and the second a group of 64 patients with 
      typical primary hyperparathyroidism (1HPT) manifesting comparable hypercalcemia. 
      The group with 1HPT differed from normal with respect to plasma PTH 1HPT 
      concentration (normal, less 0.2 ng/ml), urinary cAMP excretion per 100 ml 
      glomerular filtrate (U cAMP/GF) (normal, 2.3 x/divided by 0.6 nmol/100 ml 
      glomerular filtrate; mean, x/divided 1 SD), and renal tubular maximum of 
      phosphate transport corrected for glomerular filtration rate (TMP/GFR; normal, 
      3.4 +/- 0.4 mg/dl; mean, +/- 1 SD). The group with 1HPT also diverged 
      significantly from the group with FHH for all three indices: for PTH, 0.37 
      x/divided by .48 vs. 0.25 x/divided .46 (P less than 0.05); for UcAMP/GF, 4.3 
      x/divided by .53 vs. 2.6 x/divided .60 (P less than 0.0005); and for TMP/GFR, 2.0 
      +/- 0.6 vs. 2.6 +/- 0.7 (P less than 0.01). The between-group differences for all 
      three indices were also significant after adjustment for their variation with 
      serum calcium. However, only the difference in TMP/GFR remained significant after 
      adjustment for covariance attributable to serum calcium concentration, age, and 
      creatinine clearance. The group with FHH differed from normal for TMP/GFR but not 
      for UcAMP/GF. However, analysis of changes in UcAMP/GF and serum calcium 
      concentration around the time of parathyroidectomy in three patients with FHH 
      suggested that the parathyroid glands contributed to the abnormalities of mineral 
      homeostasis in at least one. It was concluded that higher serum concentrations of 
      PTH do not account for the lower renal clearance of calcium and magnesium in FHH 
      calcium concentration, the group with FHH showed indices suggesting lower 
      circulating PTH activity than the group with 1HPT.
FAU - Marx, S J
AU  - Marx SJ
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Brown, E M
AU  - Brown EM
FAU - Windeck, R
AU  - Windeck R
FAU - Gardner, D G
AU  - Gardner DG
FAU - Downs, R W Jr
AU  - Downs RW Jr
FAU - Attie, M
AU  - Attie M
FAU - Aurbach, G D
AU  - Aurbach GD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - E0399OZS9N (Cyclic AMP)
RN  - I38ZP9992A (Magnesium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/blood/*urine
MH  - Cyclic AMP/urine
MH  - Humans
MH  - Hypercalcemia/*genetics/metabolism/therapy
MH  - Hyperparathyroidism/*blood
MH  - Kidney Tubules/metabolism
MH  - Magnesium/blood
MH  - Parathyroid Glands/surgery
MH  - Parathyroid Hormone/*blood
MH  - Phosphates/metabolism
EDAT- 1978/12/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
AID - 10.1210/jcem-47-6-1190 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1978 Dec;47(6):1190-7. doi: 10.1210/jcem-47-6-1190.