PMID- 23369527
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130204
LR  - 20211021
IS  - 2047-1440 (Print)
IS  - 2047-1440 (Electronic)
IS  - 2047-1440 (Linking)
VI  - 1
IP  - 1
DP  - 2012 Sep 28
TI  - Human tolerogenic DC-10: perspectives for clinical applications.
PG  - 14
LID - 10.1186/2047-1440-1-14 [doi]
AB  - Dendritic cells (DCs) are critically involved in inducing either immunity or 
      tolerance. During the last decades efforts have been devoted to the development 
      of ad hoc methods to manipulate DCs in vitro to enhance or stabilize their 
      tolerogenic properties. Addition of IL-10 during monocyte-derived DC 
      differentiation allows the induction of DC-10, a subset of human tolerogenic DCs 
      characterized by high IL-10/IL-12 ratio and co-expression of high levels of the 
      tolerogenic molecules HLA-G and immunoglobulin-like transcript 4. DC-10 are 
      potent inducers of adaptive type 1 regulatory T cells, well known to promote and 
      maintain peripheral tolerance. In this review we provide an in-depth comparison 
      of the phenotype and mechanisms of suppression mediated by DC-10 and other known 
      regulatory antigen-presenting cells currently under clinical development. We 
      discuss the clinical therapeutic application of DC-10 as inducers of type 1 
      regulatory T cells for tailoring regulatory T-cell-based cell therapy, and the 
      use of DC-10 as adoptive cell therapy for promoting and restoring tolerance in 
      T-cell-mediated diseases.
FAU - Amodio, Giada
AU  - Amodio G
AD  - San Raffaele Telethon Institute for Gene Therapy (OSR-TIGET), Division of 
      Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific 
      Institute, Via Olgettina, 58, 20132, Milan, Italy. gregori.silvia@hsr.it.
FAU - Gregori, Silvia
AU  - Gregori S
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - England
TA  - Transplant Res
JT  - Transplantation research
JID - 101597592
PMC - PMC3560992
EDAT- 2013/02/02 06:00
MHDA- 2013/02/02 06:01
PMCR- 2012/09/28
CRDT- 2013/02/02 06:00
PHST- 2012/05/16 00:00 [received]
PHST- 2012/08/04 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/02 06:01 [medline]
PHST- 2012/09/28 00:00 [pmc-release]
AID - 2047-1440-1-14 [pii]
AID - 10.1186/2047-1440-1-14 [doi]
PST - epublish
SO  - Transplant Res. 2012 Sep 28;1(1):14. doi: 10.1186/2047-1440-1-14.