PMID- 23370055
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20211021
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 72
DP  - 2013 May 15
TI  - Task- and resting-state functional connectivity of brain regions related to 
      affection and susceptible to concurrent cognitive demand.
PG  - 69-82
LID - S1053-8119(13)00093-1 [pii]
LID - 10.1016/j.neuroimage.2013.01.046 [doi]
AB  - A recent fMRI-study revealed neural responses for affective processing of stimuli 
      for which overt attention irrespective of stimulus valence was required in the 
      orbitofrontal cortex (OFC) and bilateral amygdala (AMY): activation decreased 
      with increasing cognitive demand. To further characterize the network putatively 
      related to this attenuation, we here characterized these regions with respect to 
      their functional properties and connectivity patterns in task-dependent and 
      task-independent states. All experiments of the BrainMap database activating the 
      seed regions OFC and bilateral AMY were identified. Their functional 
      characteristics were quantitatively inferred using the behavioral meta-data of 
      the retrieved experiments. Task-dependent functional connectivity was 
      characterized by meta-analytic connectivity modeling (MACM) of significant 
      co-activations with these seed regions. Task-independent resting-state functional 
      connectivity analysis in a sample of 100 healthy subjects complemented these 
      analyses. All three seed regions co-activated with subgenual cingulum (SGC), 
      precuneus (PCu) and nucleus accumbens (NAcc) in the task-dependent MACM analysis. 
      Task-independent resting-state connectivity revealed significant coupling of the 
      seeds only with the SGC, but not the PCu and the NAcc. The former region (SGC) 
      moreover was shown to feature significant resting-state connectivity with all 
      other regions implicated in the network connected to regions where emotional 
      processing may be modulated by a cognitive distractor. Based on its functional 
      profile and connectivity pattern, we suggest that the SGC might serve as a key 
      hub in the identified network, as such linking autobiographic information [PCu], 
      reward [NAcc], (reinforce) values [OFC] and emotional significance [AMY]. Such a 
      role, in turn, may allow the SGC to influence the OFC and AMY to modulate 
      affective processing.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Kellermann, Tanja S
AU  - Kellermann TS
AD  - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen 
      University, Germany. Takellermann@ukaachen.de
FAU - Caspers, Svenja
AU  - Caspers S
FAU - Fox, Peter T
AU  - Fox PT
FAU - Zilles, Karl
AU  - Zilles K
FAU - Roski, Christian
AU  - Roski C
FAU - Laird, Angela R
AU  - Laird AR
FAU - Turetsky, Bruce I
AU  - Turetsky BI
FAU - Eickhoff, Simon B
AU  - Eickhoff SB
LA  - eng
GR  - R01 MH074457/MH/NIMH NIH HHS/United States
GR  - R01-MH074457-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130129
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attention/physiology
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - Emotions/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/*physiology
MH  - Rest/physiology
MH  - Young Adult
PMC - PMC4791061
MID - NIHMS765310
EDAT- 2013/02/02 06:00
MHDA- 2013/08/27 06:00
PMCR- 2016/03/14
CRDT- 2013/02/02 06:00
PHST- 2012/08/27 00:00 [received]
PHST- 2012/12/04 00:00 [revised]
PHST- 2013/01/13 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
PHST- 2016/03/14 00:00 [pmc-release]
AID - S1053-8119(13)00093-1 [pii]
AID - 10.1016/j.neuroimage.2013.01.046 [doi]
PST - ppublish
SO  - Neuroimage. 2013 May 15;72:69-82. doi: 10.1016/j.neuroimage.2013.01.046. Epub 
      2013 Jan 29.