PMID- 23370606
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20240323
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Print)
IS  - 0743-8346 (Linking)
VI  - 33
IP  - 7
DP  - 2013 Jul
TI  - Impact of early human milk on sepsis and health-care costs in very low birth 
      weight infants.
PG  - 514-9
LID - 10.1038/jp.2013.2 [doi]
AB  - OBJECTIVE: To study the incidence of sepsis and neonatal intensive care unit 
      (NICU) costs as a function of the human milk (HM) dose received during the first 
      28 days post birth for very low birth weight (VLBW) infants. STUDY DESIGN: 
      Prospective cohort study of 175 VLBW infants. The average daily dose of HM 
      (ADDHM) was calculated from daily nutritional data for the first 28 days post 
      birth (ADDHM-Days 1-28). Other covariates associated with sepsis were used to 
      create a propensity score, combining multiple risk factors into a single metric. 
      RESULT: The mean gestational age and birth weight were 28.1 +/- 2.4 weeks and 1087 
      +/- 252 g, respectively. The mean ADDHM-Days 1-28 was 54 +/- 39 ml kg(-1) day(-1) 
      (range 0-135). Binary logistic regression analysis controlling for propensity 
      score revealed that increasing ADDHM-Days 1-28 was associated with lower odds of 
      sepsis (odds ratio 0.981, 95% confidence interval 0.967-0.995, P=0.008). 
      Increasing ADDHM-Days 1-28 was associated with significantly lower NICU costs. 
      CONCLUSION: A dose-response relationship was demonstrated between ADDHM-Days 1-28 
      and a reduction in the odds of sepsis and associated NICU costs after controlling 
      for propensity score. For every HM dose increase of 10 ml kg(-1) day(-1), the 
      odds of sepsis decreased by 19%. NICU costs were lowest in the VLBW infants who 
      received the highest ADDHM-Days 1-28.
FAU - Patel, A L
AU  - Patel AL
AD  - Department of Pediatrics, Rush University Medical Center, Chicago, IL 60612, USA. 
      Aloka_Patel@Rush.edu
FAU - Johnson, T J
AU  - Johnson TJ
FAU - Engstrom, J L
AU  - Engstrom JL
FAU - Fogg, L F
AU  - Fogg LF
FAU - Jegier, B J
AU  - Jegier BJ
FAU - Bigger, H R
AU  - Bigger HR
FAU - Meier, P P
AU  - Meier PP
LA  - eng
GR  - R01 NR010009/NR/NINR NIH HHS/United States
GR  - NR010009/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130131
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
SB  - IM
CIN - J Hum Lact. 2013 Aug;29(3):339-40. PMID: 23855031
MH  - Cost of Illness
MH  - Costs and Cost Analysis
MH  - Feeding Methods
MH  - Female
MH  - Gestational Age
MH  - Health Care Costs
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/economics/*prevention & control
MH  - *Infant, Very Low Birth Weight
MH  - Intensive Care Units, Neonatal/economics
MH  - Male
MH  - *Milk, Human
MH  - Propensity Score
MH  - Prospective Studies
MH  - Sepsis/economics/*prevention & control
PMC - PMC3644388
MID - NIHMS431954
EDAT- 2013/02/02 06:00
MHDA- 2014/05/03 06:00
PMCR- 2014/01/01
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - jp20132 [pii]
AID - 10.1038/jp.2013.2 [doi]
PST - ppublish
SO  - J Perinatol. 2013 Jul;33(7):514-9. doi: 10.1038/jp.2013.2. Epub 2013 Jan 31.