PMID- 23371042
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20220321
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 30
IP  - 1
DP  - 2013 Mar
TI  - International Society of Thrombosis and Hemostasis Scoring System for 
      disseminated intravascular coagulation >/= 6: a new predictor of hemorrhagic early 
      death in acute promyelocytic leukemia.
PG  - 478
LID - 10.1007/s12032-013-0478-y [doi]
AB  - High-hemorrhagic early death (ED) rate is a major impediment in the managing of 
      acute promyelocytic leukemia (APL). In our group of 56 newly diagnosed APL 
      patients, ED occurred in 12 subjects, due to endocranial bleeding (8/12), 
      differentiation syndrome (2/12), or infection (2/12). Predictors of hemorrhagic 
      ED were as follows: white blood cells count >/= 20 x 10(9)/L (P = 0.002337), 
      Eastern cooperative oncology group performance status >/= 3 (P = 0.00173), 
      fibrinogen level <2 g/L (P = 0.004907), prothrombin time <50% (P = 0.0124), and 
      International Society of Thrombosis and Hemostasis Scoring System for 
      disseminated intravascular coagulation (ISTH DIC score) >/= 6 (P = 0.00741). 
      Multivariate analysis indicated ISTH DIC score >/= 6 to be the most significant 
      predictor for hemorrhagic ED (P = 0.008). The main finding of this study is that 
      simple coagulation-related tests, performed on hospital admission and combined in 
      the ISTH DIC score, might help to identify patients at high risk for fatal 
      bleeding needing more aggressive supportive measures.
FAU - Mitrovic, Mirjana
AU  - Mitrovic M
AD  - Clinic of Hematology, Clinical Center of Serbia, Belgrade, Serbia. mmg@beotel.net
FAU - Suvajdzic, Nada
AU  - Suvajdzic N
FAU - Bogdanovic, Andrija
AU  - Bogdanovic A
FAU - Kurtovic, Nada Kraguljac
AU  - Kurtovic NK
FAU - Sretenovic, Aleksandra
AU  - Sretenovic A
FAU - Elezovic, Ivo
AU  - Elezovic I
FAU - Tomin, Dragica
AU  - Tomin D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130131
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Coagulation Tests
MH  - Disseminated Intravascular Coagulation/*diagnosis/*etiology/*mortality
MH  - Female
MH  - Humans
MH  - Leukemia, Promyelocytic, Acute/*complications/mortality
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2013/02/02 06:00
MHDA- 2013/07/26 06:00
CRDT- 2013/02/02 06:00
PHST- 2012/12/01 00:00 [received]
PHST- 2013/01/20 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - 10.1007/s12032-013-0478-y [doi]
PST - ppublish
SO  - Med Oncol. 2013 Mar;30(1):478. doi: 10.1007/s12032-013-0478-y. Epub 2013 Jan 31.