PMID- 23372386
OWN - NLM
STAT- MEDLINE
DCOM- 20131205
LR  - 20240321
IS  - 2092-9382 (Electronic)
IS  - 1011-8942 (Print)
IS  - 1011-8942 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Feb
TI  - Spectral-domain optical coherence tomography of combined hamartoma of the retina 
      and retinal pigment epithelium in neurofibromatosis.
PG  - 68-71
LID - 10.3341/kjo.2013.27.1.68 [doi]
AB  - A 5-year-old girl was diagnosed with neurofibromatosis type 2 (NF-2) due to 
      multiple neurofibromas, cafe-au-lait spots, and schwannomas of the brain. During 
      ophthalmologic evaluation, a posterior subcapsular cataract and a gray-green 
      colored subretinal lesion were found in right eye. Fluorescein angiography (FA) 
      revealed a combined hamartoma of the retina and retinal pigment epithelium 
      (CHRRPE). At age 9, she underwent cataract surgery. At this time FA and 
      spectral-domain optical coherence tomography (SD-OCT) were taken. The SD-OCT 
      showed an elevated hyperreflective mass in the retina with prominent attenuation 
      of the inner and outer retina, but minimal attenuation in the photoreceptor 
      layers. The underlying retina appeared to be disorganized and thick (791 microm). 
      This is the first case report of SD-OCT imaging of a CHRRPE associated with NF-2 
      in a pediatric patient. By using SD-OCT in this patient, we could obtain detailed 
      tumor characteristics, and SD-OCT may be helpful in the diagnosis and management 
      of CHRRPE.
FAU - Kang, Hae Min
AU  - Kang HM
AD  - Department of Ophthalmology, Institute of Vision Research, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Koh, Hyoung Jun
AU  - Koh HJ
FAU - Chung, Eun Jee
AU  - Chung EJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20121218
PL  - Korea (South)
TA  - Korean J Ophthalmol
JT  - Korean journal of ophthalmology : KJO
JID - 8804513
SB  - IM
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Female
MH  - Hamartoma/complications/*diagnosis
MH  - Humans
MH  - Neurofibromatosis 2/*complications/diagnosis
MH  - Retinal Diseases/complications/*diagnosis
MH  - Retinal Pigment Epithelium/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
PMC - PMC3550318
OTO - NOTNLM
OT  - Combined hamartoma of retina and retinal pigment epithelium
OT  - Neurofibromatoses
OT  - Spectral-domain optical coherence tomography
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/02/02 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/02/01
CRDT- 2013/02/02 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.3341/kjo.2013.27.1.68 [doi]
PST - ppublish
SO  - Korean J Ophthalmol. 2013 Feb;27(1):68-71. doi: 10.3341/kjo.2013.27.1.68. Epub 
      2012 Dec 18.