PMID- 23373028
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130204
LR  - 20211021
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 6
IP  - 10
DP  - 2012 Dec
TI  - Antidiabetic and hypolipidemic effect of salacia oblonga in streptozotocin 
      induced diabetic rats.
PG  - 1685-7
LID - 10.7860/JCDR/2012/4728.2644 [doi]
AB  - OBJECTIVES: The present study was conducted to evaluate the effect of a 
      standardized hydroalcoholic root extract of Sala notcia oblonga (SOE) on the Random 
      Blood Glucose (RBG) levels, serum insulin, glycated haemoglobin (HbA1c) and the 
      serum lipid profile in long standing, experimentally induced Diabetes Mellitus 
      (DM) with glibenclamide (Glb) as the standard. MATERIALS AND METHODS: 
      Streptozotocin (STZ) induced, dia-betic, Wistar rats of either sex were treated 
      with two oral doses of SOE, 100 and 50mg/kg body wt /day, for a period of 16 
      weeks. The RBG was estimated at day-1 and at the end of the 16 weeks by using a 
      glucometer. The fasting serum insulin was determined by an ELISA technique. The 
      plasma HbA1c was evaluated by a Turbidimetric Inhibition Immunoassay (TINIA) and 
      the lipid profile was estimated enzymatically. RESULTS AND ANALYSIS: A 45% 
      decrease in the RBG was seen after the treatment with the higher dose of SOE, 
      whereas a 44% decrease was observed with the lower dose as com notpared to the 
      diabetic control. Serum insulin was significantly increased (P<0.05) in all the 
      treated groups as compared to the diabetic control. Plasma HbA1c was 
      significantly decreased (P<0.05). The serum Triacyl Glycerol (TG) levels were 
      signifi notcantly decreased (P<0.05) in the treated rats as compared to the diabetic 
      control. A significant increase in HDL-cholesterol (P<0.05) in the diabetic rats 
      as a result of the 100mg/kg SOE treatment was a remarkable finding. CONCLUSION: 
      SOE improves the glycaemic parameters in diabetic rats after a prolonged 
      treatment. The serum TG levels were normalized on treatment. A higher dose of the 
      extract could not alter the parameters significantly, except for HDL-C.
FAU - Bhat, Bhagyajyothi M
AU  - Bhat BM
AD  - Senior Research Fellow, Department of Biochemistry, Kasturba Medical College , 
      Mangalore, India.
FAU - C V, Raghuveer
AU  - C V R
FAU - D'Souza, Vivian
AU  - D'Souza V
FAU - Manjrekar, Poornima A
AU  - Manjrekar PA
LA  - eng
PT  - Journal Article
DEP - 20121215
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3552204
OTO - NOTNLM
OT  - Blood glucose
OT  - Lipid profile
OT  - S. oblonga
OT  - STZ- Rats
EDAT- 2013/02/02 06:00
MHDA- 2013/02/02 06:01
PMCR- 2013/02/01
CRDT- 2013/02/02 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/11/01 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/02 06:01 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2012/4728.2644 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2012 Dec;6(10):1685-7. doi: 10.7860/JCDR/2012/4728.2644. Epub 
      2012 Dec 15.