PMID- 23373240
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20171116
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 21
DP  - 2012 Nov
TI  - [Correlation study between OPN, CD44v6, MMP-9 and distant metastasis in laryngeal 
      squamous cell carcinoma].
PG  - 989-92
AB  - OBJECTIVE: To investigate the expression and clinical significance of OPN, CD44v6 
      and MMP-9 in laryngeal squamous cell carcinomas (LSCC). METHOD: The expression of 
      OPN, CD44v6 and MMP-9 in the 47 cases of LSCC and 10 cases normal mucosa were 
      detected by immunohistochemical method. The correlation between OPN, CD44v6 and 
      MMP-9 proteins expressions and the correlation between them and 
      clinicopathological feature were also studied. RESULT: (1) The positive 
      expression rates of OPN, CD44v6 and MMP-9 were 63.8%, 76.6% and 68.1% in LSCC of 
      47 cases and, and 10%, 30% and 0 in the tumor adjacent issue. (2) The positive 
      rate of OPN and CD44v6 was significantly correlated with the clinical staging, 
      the pathological grading and the metastasis of cervical lymph node (P < 0.05). 
      The positive rate of MMP-9 was correlated with the clinical staging and the 
      metastasis of cervical lymph node (P < 0.05). The positive rates of OPN, CD44v6 
      and MMP-9 were not correlated with patient's age, sex and tumor location (P > 
      0.05). (3) The expression of OPN was well correlated with the positive rate of 
      CD44v6 and MMP-9 in LSCC (r = 0.421, P < 0.01, r = 0.340, P < 0.05). The 
      expression of positive rate of CD44v6 and MMP-9 was well related in LSCC as well 
      (r = 0.376, P < 0.01). CONCLUSION: There is a high level of expression of OPN, 
      CD44v6 and MMP-9 in LSCC. OPN, CD44v6 and MMP-9 are positively related and 
      involved in the invasion and metastasis of LSCC.
FAU - Yang, Lihua
AU  - Yang L
AD  - Hebei North University, Zhangjiakou, 075000, China.
FAU - Shang, Xiaoling
AU  - Shang X
FAU - Zhao, Xiufang
AU  - Zhao X
FAU - Lin, Yuanyuan
AU  - Lin Y
FAU - Liu, Junchao
AU  - Liu J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CD44v6 antigen)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (SPP1 protein, human)
RN  - 106441-73-0 (Osteopontin)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Laryngeal Neoplasms/metabolism/*pathology
MH  - Male
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Osteopontin/*metabolism
MH  - Prognosis
EDAT- 2013/02/05 06:00
MHDA- 2013/08/16 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Nov;26(21):989-92.