PMID- 23374533
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130214
LR  - 20211021
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Feb 3
TI  - Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, 
      oxidative stress and inflammation in rats.
PG  - 20
LID - 10.1186/1743-7075-10-20 [doi]
AB  - This study investigated the protective effects of melatonin and folic acid 
      against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Oxidative 
      stress, liver function, liver histopathology and serum lipid levels were 
      evaluated. The levels of protein kinase B (Akt1), interferon gamma (IFN-gamma), 
      programmed cell death-receptor (Fas) and Tumor necrosis factor-alpha (TNF-alpha) mRNA 
      expression were analyzed. CCl4 significantly elevated the levels of lipid 
      peroxidation (MDA), cholesterol, LDL, triglycerides, bilirubin and urea. In 
      addition, CCl4 was found to significantly suppress the activity of both catalase 
      and glutathione (GSH) and decrease the levels of serum total protein and 
      HDL-cholesterol. All of these parameters were restored to their normal levels by 
      treatment with melatonin, folic acid or their combination. An improvement of the 
      general hepatic architecture was observed in rats that were treated with the 
      combination of melatonin and folic acid along with CCl4. Furthermore, the 
      CCl4-induced upregulation of TNF-alpha and Fas mRNA expression was significantly 
      restored by the three treatments. Melatonin, folic acid or their combination also 
      restored the baseline levels of IFN-gamma and Akt1 mRNA expression. The combination 
      of melatonin and folic acid exhibited ability to reduce the markers of liver 
      injury induced by CCl4 and restore the oxidative stability, the level of 
      inflammatory cytokines, the lipid profile and the cell survival Akt1 signals.
FAU - Ebaid, Hossam
AU  - Ebaid H
AD  - Department of Zoology, College of Science, King Saud University, KSA, P,O,Box, 
      2455, Riyadh, 11451, Saudi Arabia. hossamebaid@yahoo.com.
FAU - Bashandy, Samir Ae
AU  - Bashandy SA
FAU - Alhazza, Ibrahim M
AU  - Alhazza IM
FAU - Rady, Ahmed
AU  - Rady A
FAU - El-Shehry, Sultan
AU  - El-Shehry S
LA  - eng
PT  - Journal Article
DEP - 20130203
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC3570377
EDAT- 2013/02/05 06:00
MHDA- 2013/02/05 06:01
PMCR- 2013/02/03
CRDT- 2013/02/05 06:00
PHST- 2012/09/29 00:00 [received]
PHST- 2013/01/22 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/02/05 06:01 [medline]
PHST- 2013/02/03 00:00 [pmc-release]
AID - 1743-7075-10-20 [pii]
AID - 10.1186/1743-7075-10-20 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2013 Feb 3;10(1):20. doi: 10.1186/1743-7075-10-20.