PMID- 23374967
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20130204
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 106
IP  - 1
DP  - 2013 Jan
TI  - Slower heart rate and altered rate dependence of ventricular repolarization in 
      patients with lone atrial fibrillation.
PG  - 12-8
LID - S1875-2136(12)00291-4 [pii]
LID - 10.1016/j.acvd.2012.10.001 [doi]
AB  - BACKGROUND: Electrophysiological alterations in atrial fibrillation (AF) may be 
      genetically based and may lead to changes in ventricular repolarization. Short QT 
      syndrome is a rare channelopathy with abbreviated ventricular repolarization and 
      a propensity for AF. AIMS: To determine if minor unrecognized forms of short QT 
      syndrome can explain some cases of lone AF. METHODS: We prospectively compared QT 
      intervals in 66 patients with idiopathic lone AF and 132 age- and sex-matched 
      controls. QT intervals were measured during sinus rhythm in each of the 12 
      surface electrocardiogram leads and corrected using Bazett's formula (QTc). QT 
      intervals were also corrected using other formulae. Uncorrected QT and heart rate 
      regression lines were compared between AF patients and controls. RESULTS: AF 
      patients presented with a slower resting heart rate (64 +/- 10 beats per minute 
      [bpm] vs 69 +/- 9 bpm; P=0.0006). QTc intervals were shorter in AF patients in 
      11/12 electrocardiogram leads (significant in 7/12, borderline in 2/12; mean QTc 
      381 +/- 21 ms vs 388 +/- 22 ms; P=0.02). QTc intervals were also shorter in AF 
      patients, significantly or not, using other correction formulae. For similar 
      heart rates, uncorrected QT intervals were shorter in patients when heart rates 
      were greater than 70 bpm and longer when heart rates were less than 60 bpm. AF 
      patients displayed steeper QT/heart rate regression line slopes than controls 
      (P=0.009). CONCLUSION: Heart rate is significantly slower and the rate dependence 
      of ventricular repolarization is significantly altered in patients with lone AF 
      compared with controls. Further study is warranted to determine if AF induces 
      subsequent ventricular repolarization changes or if these modifications are 
      caused by an underlying primary electrical disease.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Maury, Philippe
AU  - Maury P
AD  - Federation of Cardiology, University Hospital Rangueil, Toulouse, France. 
      mauryjphil@hotmail.com
FAU - Caudron, Guillaume
AU  - Caudron G
FAU - Bouisset, Frederic
AU  - Bouisset F
FAU - Fourcade, Joelle
AU  - Fourcade J
FAU - Duparc, Alexandre
AU  - Duparc A
FAU - Mondoly, Pierre
AU  - Mondoly P
FAU - Rollin, Anne
AU  - Rollin A
FAU - Hascoet, Sebastien
AU  - Hascoet S
FAU - Detis, Nicolas
AU  - Detis N
FAU - Cardin, Christelle
AU  - Cardin C
FAU - Delay, Marc
AU  - Delay M
FAU - Lairez, Olivier
AU  - Lairez O
FAU - Roncalli, Jerome
AU  - Roncalli J
FAU - Galinier, Michel
AU  - Galinier M
FAU - Carrie, Didier
AU  - Carrie D
FAU - Elbaz, Meyer
AU  - Elbaz M
FAU - Ferrieres, Jean
AU  - Ferrieres J
FAU - Fauvel, Jean-Marie
AU  - Fauvel JM
FAU - Zimmermann, Marc
AU  - Zimmermann M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121229
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
SB  - IM
MH  - Atrial Fibrillation/diagnosis/*physiopathology
MH  - Bradycardia/diagnosis/*physiopathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Electrocardiography
MH  - France
MH  - Heart Conduction System/*physiopathology
MH  - *Heart Rate
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Switzerland
MH  - Time Factors
EDAT- 2013/02/05 06:00
MHDA- 2013/07/28 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/07/28 00:00 [received]
PHST- 2012/09/27 00:00 [revised]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
AID - S1875-2136(12)00291-4 [pii]
AID - 10.1016/j.acvd.2012.10.001 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2013 Jan;106(1):12-8. doi: 10.1016/j.acvd.2012.10.001. Epub 
      2012 Dec 29.