PMID- 23375122
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20220321
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 61
IP  - 3
DP  - 2013 Mar
TI  - Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic 
      biomarker in the pathogenesis of chronic periodontal disease.
PG  - 892-7
LID - S1043-4666(12)00822-8 [pii]
LID - 10.1016/j.cyto.2012.12.012 [doi]
AB  - OBJECTIVE: Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine 
      responsible for the initiation, regulation and mobilization of monocytes to the 
      active sites of severe periodontal inflammation. The present study aims at 
      evaluating the levels of MCP-1 in GCF, saliva and serum and to analyze the 
      changes following phase I periodontal therapy. Assessment of possible 
      correlations between levels of MCP-1 in the three biological fluids was also 
      done. METHODS: Fifteen healthy and 30 patients of severe chronic periodontitis 
      (diseased) participated in the study. Patients of the diseased group underwent 
      scaling/root planing. Evaluation of PI, GI, PD, CAL and collection of samples of 
      GCF, serum and saliva was done at baseline and 6 weeks following periodontal 
      therapy. MCP-1 levels were quantified in all samples using ELISA. RESULTS: 
      Compared to healthy controls, MCP-1 levels were statistically significantly 
      higher in GCF (p<0.001), saliva (p=0.002) and serum (p<0.001) in subjects with 
      chronic periodontitis. Levels of MCP-1 in all the three fluids decreased 
      significantly in patients after periodontal therapy (p<0.001). There was a 
      significant positive correlation between MCP-1 levels in GCF, saliva and serum in 
      patients of chronic periodontitis both pre (r>0.9) and post-treatment (r>0.6). 
      CONCLUSIONS: The results suggest that levels of MCP-1 in GCF and saliva can be 
      reliable indicators of severity of periodontal destruction and their serum levels 
      reflect the systemic impact of this local inflammatory disease thereby 
      strengthening the reciprocal oro-systemic association.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Gupta, Mili
AU  - Gupta M
AD  - Department of Biochemistry, Dr. Harvansh Singh Judge, Institute of Dental 
      Sciences & Hospital, Panjab University, Chandigarh, India. miligupta8@yahoo.com
FAU - Chaturvedi, Rashi
AU  - Chaturvedi R
FAU - Jain, Ashish
AU  - Jain A
LA  - eng
PT  - Journal Article
DEP - 20130130
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*metabolism
MH  - Chronic Periodontitis/blood/*diagnosis/etiology/*immunology
MH  - Female
MH  - Gingival Crevicular Fluid/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Saliva/metabolism
EDAT- 2013/02/05 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/08/30 00:00 [received]
PHST- 2012/12/06 00:00 [revised]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - S1043-4666(12)00822-8 [pii]
AID - 10.1016/j.cyto.2012.12.012 [doi]
PST - ppublish
SO  - Cytokine. 2013 Mar;61(3):892-7. doi: 10.1016/j.cyto.2012.12.012. Epub 2013 Jan 
      30.