PMID- 23375553
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20221207
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 122
DP  - 2013 Apr
TI  - Exposure to persistent organic pollutants and risk of hypertension among Inuit 
      from Greenland.
PG  - 65-73
LID - S0013-9351(12)00345-3 [pii]
LID - 10.1016/j.envres.2012.12.006 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) is of concern in 
      Arctic populations since these contaminants accumulate in fish and marine 
      mammals, which is an important part of the traditional diet of these populations. 
      Epidemiological and experimental studies have reported significant associations 
      between POPs and increased blood pressure (BP) in populations with different 
      degrees of exposure. OBJECTIVE: We aimed to assess the risk of hypertension 
      related to increasing levels of polychlorinated biphenyls (PCBs) and 
      organochlorine (OC) pesticides. METHODS: Fifteen PCBs and 11 OC pesticides or 
      their metabolites were determined in plasma of 1614 Inuit adults >/= 18 years 
      living in 9 towns and 13 villages in Greenland. BP was measured using a 
      standardized protocol. The risk of hypertension was estimated through logistic 
      regression using POPs as continuous variables (log-transformed). Hypertension was 
      defined as systolic BP >/= 140 mm Hg, diastolic BP >/= 90 mm Hg and/or 
      antihypertensive treatment. RESULTS: Overall, the odd ratios (ORs) of 
      hypertension were not statistically significant for dioxin-like PCBs, 
      non-dioxin-like PCBs and OC pesticides after adjusting for confounders. Once the 
      analyses were stratified by age category (18-39 and >/= 40 years), increased risk 
      of hypertension was observed for total dioxin-like PCBs among the youngest [OR: 
      1.34 (95% CI: 1.03-1.74)] while a borderline protective effect was observed for 
      total non-dioxin-like PCBs [OR: 0.81 (95% CI: 0.66-0.99)] among the oldest. 
      Higher risk of hypertension was also associated with increasing 
      p,p'-dichlorodiphenyltrichloroethane (DDT) concentrations among the youngest [OR: 
      1.42 (95% CI: 1.08-1.85)]. CONCLUSION: Overall, no significant associations were 
      observed between PCBs, OC pesticides and blood pressure in this highly exposed 
      population although the associations differed by age category.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Valera, Beatriz
AU  - Valera B
AD  - National Institute of Public health, Copenhagen, Denmark. 
      beatriz.valera@crchul.ulaval.ca
FAU - Jorgensen, Marit E
AU  - Jorgensen ME
FAU - Jeppesen, Charlotte
AU  - Jeppesen C
FAU - Bjerregaard, Peter
AU  - Bjerregaard P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130130
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - FXS1BY2PGL (Mercury)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Blood Pressure/drug effects
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/adverse effects
MH  - Fatty Acids, Omega-3/pharmacology
MH  - Female
MH  - Greenland/epidemiology
MH  - Humans
MH  - Hypertension/*chemically induced/*epidemiology
MH  - Inuit/*statistics & numerical data
MH  - Male
MH  - Mercury/toxicity
MH  - Middle Aged
MH  - Pesticides/blood/*toxicity
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Selenium/toxicity
EDAT- 2013/02/05 06:00
MHDA- 2013/05/15 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/10/07 00:00 [received]
PHST- 2012/12/14 00:00 [revised]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - S0013-9351(12)00345-3 [pii]
AID - 10.1016/j.envres.2012.12.006 [doi]
PST - ppublish
SO  - Environ Res. 2013 Apr;122:65-73. doi: 10.1016/j.envres.2012.12.006. Epub 2013 Jan 
      30.