PMID- 23375675
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20131018
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 209
IP  - 3
DP  - 2013 Oct 30
TI  - Serum levels of brain-derived neurotrophic factor in patients with internet use 
      disorder.
PG  - 525-8
LID - S0165-1781(12)00817-7 [pii]
LID - 10.1016/j.psychres.2012.12.020 [doi]
AB  - Internet use disorder (IUD) is characterised by excessive internet gaming use and 
      has temporarily been conceptualised as a behavioural addiction. Since 
      brain-derived neurotrophic factor (BDNF) has been hypothesised to be involved in 
      the development and maintenance of addictive disorders, we investigated BDNF 
      expression in IUD. We measured BDNF serum levels in male patients with IUD (n=11) 
      and individually matched healthy controls (n=10). There was no significant 
      difference in BDNF serum levels of patients with IUD in comparison to control 
      subjects. Serum levels of BDNF were not correlated with severity of IUD or 
      clinical and demographic variables in our study. These preliminary findings 
      possibly suggest a different underlying pathophysiology in IUD compared to 
      addictive disorders. Thus, further studies are needed to clarify, whether IUD 
      represents an addictive spectrum disorder, an impulse control disorder or finally 
      an individual diagnostic entity that overlaps with both disease categories.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Geisel, Olga
AU  - Geisel O
AD  - Department of Psychiatry, Campus Charite Mitte, Charite - Universitatsmedizin 
      Berlin, Chariteplatz 1, 10117 Berlin, Germany.
FAU - Banas, Roman
AU  - Banas R
FAU - Schneider, Michael
AU  - Schneider M
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Muller, Christian A
AU  - Muller CA
LA  - eng
PT  - Journal Article
DEP - 20130131
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Behavior, Addictive/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Statistics, Nonparametric
MH  - Young Adult
OTO - NOTNLM
OT  - Behavioural addiction
OT  - Brain-derived neurotrophic factor
OT  - Internet addiction
OT  - Internet use disorder
EDAT- 2013/02/05 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/09/02 00:00 [received]
PHST- 2012/12/11 00:00 [revised]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - S0165-1781(12)00817-7 [pii]
AID - 10.1016/j.psychres.2012.12.020 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Oct 30;209(3):525-8. doi: 10.1016/j.psychres.2012.12.020. 
      Epub 2013 Jan 31.