PMID- 23376084
OWN - NLM
STAT- MEDLINE
DCOM- 20131025
LR  - 20220408
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 5
DP  - 2013 May
TI  - A meta-analysis about the association between -1082G/A and -819C/T polymorphisms 
      of IL-10 gene and risk of type 2 diabetes.
PG  - 618-26
LID - S0198-8859(13)00032-3 [pii]
LID - 10.1016/j.humimm.2013.01.021 [doi]
AB  - The present meta-analysis was conducted to investigate the association between 
      the -1082G/A and -819C/T polymorphisms of the IL-10 gene and risk of type 2 
      diabetes mellitus (T2DM). Relevant articles were identified by searching PubMed, 
      Embase, and Web of Science. Pooled odds ratios (ORs) were used to assess the 
      strength of the association between target polymorphisms and the risk of T2DM. 
      Significant associations between the -1082G/A polymorphism and T2DM were found 
      for the allele contrast (OR=0.90, 95% CI: [0.83, 0.98], P=0.02), homozygote 
      contrast (OR=0.82, 95% CI: [0.69, 0.97], P=0.02), and recessive genetic model 
      (OR=0.85, 95% CI: [0.74, 0.96], P=0.01). However, no significant association was 
      found for the dominant genetic model (OR=0.91, 95% CI: [0.80, 1.05], P=0.08). The 
      association between -819C/T polymorphism and T2DM was significant for the allele 
      contrast (OR=0.73, 95% CI: [0.64, 0.84], P<0.01); however, no significant 
      associations were found for -819C/T in the homozygote contrast (OR=1.01, 95% CI: 
      [0.38, 2.67], P=0.99), dominant genetic model (OR=0.94, 95% CI: [0.50, 1.77], 
      P=0.86), and recessive genetic model (OR=0.92, 95% CI: [0.50, 1.68], P=0.78). No 
      significant publication bias was detected. This meta-analysis suggests that 
      allele A of -1082G/A and allele C of -819C/T in the IL-10 gene have potentially 
      protective effects in terms of risk of T2DM.
CI  - Crown Copyright (c) 2013. Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Fan
AU  - Zhang F
AD  - School of Public Health and Health Management, Chongqing Medical University, 
      Chongqing, China.
FAU - Yang, Yuan
AU  - Yang Y
FAU - Lei, Han
AU  - Lei H
FAU - Qiu, Jingfu
AU  - Qiu J
FAU - Wang, Yang
AU  - Wang Y
FAU - Hu, Dayi
AU  - Hu D
FAU - Skrip, Laura
AU  - Skrip L
FAU - Chen, Fangchun
AU  - Chen F
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20130131
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2013/02/05 06:00
MHDA- 2013/10/26 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/09/25 00:00 [received]
PHST- 2012/12/06 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/10/26 06:00 [medline]
AID - S0198-8859(13)00032-3 [pii]
AID - 10.1016/j.humimm.2013.01.021 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 May;74(5):618-26. doi: 10.1016/j.humimm.2013.01.021. Epub 2013 
      Jan 31.