PMID- 23376487
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20240322
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 63
IP  - 3
DP  - 2013 Mar
TI  - Central expression and anorectic effect of brain-derived neurotrophic factor are 
      regulated by circulating estradiol levels.
PG  - 533-42
LID - S0018-506X(13)00028-7 [pii]
LID - 10.1016/j.yhbeh.2013.01.009 [doi]
AB  - Estrogens potently suppress food intake. Compelling evidence suggests that 
      estradiol, the primary form of estrogens, reduces food intake by facilitating 
      other anorectic signals. Brain-derived neurotrophic factor (BDNF), like 
      estradiol, appears to suppress food intake by affecting meal size. We 
      hypothesized that estradiol modulates Bdnf expression and the anorectic effect of 
      BDNF. The first goal was to determine whether Bdnf expression was regulated by 
      endogenous estradiol of cycling rats and by cyclic estradiol treatment using 
      ovariectomized rats. Bdnf expression within the ventromedial nucleus of 
      hypothalamus (VMH) was temporally elevated at estrus following the estradiol 
      peak, which coincided with the decline in feeding at this phase of the ovarian 
      cycle. Additionally, food intake and body weight were increased following 
      ovariectomy with a parallel decrease in Bdnf expression in the VMH. All of these 
      alterations were reversed by cyclic estradiol treatment, suggesting that Bdnf 
      expression within the VMH was regulated in an estradiol-dependent manner. The 
      second goal was to determine whether estradiol modulates the anorectic effect of 
      BDNF. Sham-operated estrous rats and ovariectomized rats cyclically treated with 
      estradiol responded to a lower dose of central administration of BDNF to decrease 
      food intake than male rats and oil-treated ovariectomized rats, implying that 
      endogenous estradiol or cyclic estradiol replacement increased the sensitivity to 
      anorectic effect of BDNF. These data indicate that Bdnf expression within the VMH 
      and the anorectic effect of BDNF varied depending on plasma estradiol levels, 
      suggesting that estradiol may regulate BDNF signaling to regulate feeding.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Zhu, Zheng
AU  - Zhu Z
AD  - Center for Physiology and Neuroscience, Department of Biology, Miami University, 
      Oxford, OH, USA.
FAU - Liu, Xian
AU  - Liu X
FAU - Senthil Kumar, Shiva Priya Dharshan
AU  - Senthil Kumar SP
FAU - Zhang, Jing
AU  - Zhang J
FAU - Shi, Haifei
AU  - Shi H
LA  - eng
GR  - R15 DK090823/DK/NIDDK NIH HHS/United States
GR  - DK090823/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130131
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/physiology
MH  - Eating/drug effects/*physiology
MH  - Estradiol/administration & dosage/*blood
MH  - Estrogens/administration & dosage/pharmacology
MH  - *Estrous Cycle/blood/metabolism
MH  - Female
MH  - Male
MH  - Ovariectomy/methods
MH  - Rats
MH  - Rats, Long-Evans
MH  - Ventromedial Hypothalamic Nucleus/*metabolism/physiology
PMC - PMC3624754
MID - NIHMS454432
EDAT- 2013/02/05 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/03/01
CRDT- 2013/02/05 06:00
PHST- 2012/09/22 00:00 [received]
PHST- 2013/01/15 00:00 [revised]
PHST- 2013/01/21 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - S0018-506X(13)00028-7 [pii]
AID - 10.1016/j.yhbeh.2013.01.009 [doi]
PST - ppublish
SO  - Horm Behav. 2013 Mar;63(3):533-42. doi: 10.1016/j.yhbeh.2013.01.009. Epub 2013 
      Jan 31.