PMID- 23377009
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 18
IP  - 2
DP  - 2013 Feb
TI  - Continuous haematic pH monitoring in extracorporeal circulation using a 
      disposable florescence sensing element.
PG  - 27002
LID - 10.1117/1.JBO.18.2.027002 [doi]
AB  - During extracorporeal circulation (ECC), blood is periodically sampled and 
      analyzed to maintain the blood-gas status of the patient within acceptable 
      limits. This protocol has well-known drawbacks that may be overcome by continuous 
      monitoring. We present the characterization of a new pH sensor for continuous 
      monitoring in ECC. This monitoring device includes a disposable 
      fluorescence-sensing element directly in contact with the blood, whose 
      fluorescence intensity is strictly related to the pH of the blood. In vitro 
      experiments show no significant difference between the blood gas analyzer values 
      and the sensor readings; after proper calibration, it gives a correlation of 
      R>0.9887, and measuring errors were lower than the 3% of the pH range of interest 
      (RoI) with respect to a commercial blood gas analyzer. This performance has been 
      confirmed also by simulating a moderate ipothermia condition, i.e., blood 
      temperature 32 degrees C, frequently used in cardiac surgery. In ex vivo experiments, 
      performed with animal models, the sensor is continuously operated in an 
      extracorporeal undiluted blood stream for a maximum of 11 h. It gives a 
      correlation of R>0.9431, and a measuring error lower than the 3% of the pH RoI 
      with respect to laboratory techniques.
FAU - Ferrari, Luca
AU  - Ferrari L
AD  - University of Modena and Reggio Emilia, Department of Engineering Enzo Ferrari, 
      Strada Vignolese 905, I-41125, Modena, Italy. luca.ferrari@unimore.it
FAU - Rovati, Luigi
AU  - Rovati L
FAU - Fabbri, Paola
AU  - Fabbri P
FAU - Pilati, Francesco
AU  - Pilati F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Animals
MH  - Blood/*metabolism
MH  - Blood Gas Analysis/instrumentation/statistics & numerical data
MH  - *Extracorporeal Circulation
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Monitoring, Physiologic/*instrumentation/statistics & numerical data
MH  - Optical Devices
MH  - Optical Fibers
MH  - Optical Phenomena
MH  - Sheep, Domestic
MH  - Spectrometry, Fluorescence/*instrumentation/statistics & numerical data
MH  - Sus scrofa
MH  - Transducers
EDAT- 2013/02/05 06:00
MHDA- 2013/09/07 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - 1566741 [pii]
AID - 10.1117/1.JBO.18.2.027002 [doi]
PST - ppublish
SO  - J Biomed Opt. 2013 Feb;18(2):27002. doi: 10.1117/1.JBO.18.2.027002.