PMID- 23377582
OWN - NLM
STAT- MEDLINE
DCOM- 20141121
LR  - 20140603
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 23
IP  - 5
DP  - 2014 Jun-Jul
TI  - Diagnostic ability of spectral-domain versus time-domain optical coherence 
      tomography in preperimetric glaucoma.
PG  - 299-306
LID - 10.1097/IJG.0b013e3182741cc4 [doi]
AB  - PURPOSE: To evaluate and compare the diagnostic abilities of the speckle 
      noise-reduced spectral-domain optical coherence tomography (SD-OCT; Spectralis 
      OCT) and time-domain optical coherence tomography (TD-OCT; Stratus OCT) to detect 
      localized retinal nerve fiber layer (RNFL) defects in patients with preperimetric 
      open-angle glaucoma. METHODS: Thirty-five eyes of 35 preperimetric glaucoma 
      patients with localized RNFL defects and 72 normal control eyes were scanned 
      using SD-OCT and TD-OCT. Areas under the receiver-operating characteristic curves 
      (AUROCs), and the sensitivity and specificity for detecting localized RNFL 
      defects based on the internal normative database of each device were calculated 
      and compared. RESULTS: The AUROC for the best parameter from SD-OCT 
      (inferotemporal sector, AUROC=0.940) was significantly higher than that of TD-OCT 
      (7 o'clock sector, AUROC=0.881; P=0.009). The sensitivity of the SD-OCT 
      parameters ranged from 18.9% to 83.8% and that of the TD-OCT parameters ranged 
      from 5.4% to 54.1%, with the criterion of abnormal at the 5% level. The highest 
      sensitivity of the SD-OCT was found with the 
      temporal-superior-nasal-inferior-temporal thickness graph abnormal at the 5% 
      level, which had a specificity of 90.3%. On the basis of 
      temporal-superior-nasal-inferior-temporal thickness graphs, SD-OCT was more 
      sensitive (P=0.001) for detection of preperimetric RNFL defects than TD-OCT at a 
      comparable specificity (P=0.227). CONCLUSIONS: Speckle noise-reduced SD-OCT is 
      better able to detect preperimetric localized RNFL defect(s) than TD-OCT.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - *Department of Ophthalmology, Seoul National University College of Medicine 
      daggerDepartment of Ophthalmology, Seoul National University Hospital  parallelDepartment of 
      Ophthalmology, Seoul National University Boramae Hospital, Seoul double daggerDepartment of 
      Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea 
       section signHamilton Glaucoma Center and Department of Ophthalmology, University of 
      California San Diego, La Jolla, CA.
FAU - Kim, Tae-Woo
AU  - Kim TW
FAU - Weinreb, Robert N
AU  - Weinreb RN
FAU - Kim, Seok Hwan
AU  - Kim SH
FAU - Park, Ki Ho
AU  - Park KH
FAU - Kim, Dong Myung
AU  - Kim DM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - Time Factors
MH  - Tomography, Optical Coherence/*instrumentation/methods
MH  - Tonometry, Ocular
MH  - Visual Field Tests
MH  - Visual Fields
MH  - Young Adult
EDAT- 2013/02/05 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1097/IJG.0b013e3182741cc4 [doi]
PST - ppublish
SO  - J Glaucoma. 2014 Jun-Jul;23(5):299-306. doi: 10.1097/IJG.0b013e3182741cc4.