PMID- 23377901
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20240109
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 102
IP  - 5
DP  - 2013 May
TI  - Systemic right ventricles rarely show myocardial scars in cardiac magnetic 
      resonance delayed-enhancement imaging.
PG  - 337-44
LID - 10.1007/s00392-013-0539-4 [doi]
AB  - OBJECTIVES: To test the hypothesis that myocardial scars cause systolic 
      dysfunction in patients with transposition of the great arteries and a systemic 
      right ventricle. METHODS: We retrospectively analyzed 20 consecutive patients (10 
      male, mean age 27.3 years) with a systemic right ventricle who underwent cardiac 
      magnetic resonance imaging with 1.5 T. Cine steady-state free-precession 
      sequences were performed to obtain volumes and function. Phase-sensitive 
      inversion-recovery (PSIR) delayed-enhancement imaging was performed to detect 
      myocardial scars. Tricuspid insufficiency was detected with echocardiography. 
      Furthermore, the presence of arrhythmias and New York Heart Association (NYHA) 
      class were assessed. RESULTS: Mean ejection fraction of systemic right ventricles 
      was 43 +/- 11 %, mean end-diastolic volume index was 111 +/- 37 ml/m(2). 
      Delayed-enhancement imaging revealed only one myocardial scar in the wall of a 
      right ventricular aneurysm. All patients but one (95 %) presented with tricuspid 
      insufficiency. Clinically relevant arrhythmias were present in 13/20 patients (65 
      %). The majority of patients (90 %) were NYHA class I or II. Arrhythmias, 
      tricuspid insufficiency and NYHA class were not associated with right ventricular 
      ejection fraction. CONCLUSIONS: Although right ventricular function was clearly 
      impaired in our patient cohort, there was only one myocardial scar. Our results 
      show that myocardial scarring assessed by PSIR delayed-enhancement imaging is not 
      the underlying pathology of systemic right ventricular failure.
FAU - Preim, Uta
AU  - Preim U
AD  - University of Leipzig, Heart Center, Leipzig, Germany. uta.preim@googlemail.com
FAU - Hoffmann, Janine
AU  - Hoffmann J
FAU - Lehmkuhl, Lukas
AU  - Lehmkuhl L
FAU - Kehrmann, Jana
AU  - Kehrmann J
FAU - Riese, Franziska
AU  - Riese F
FAU - Daehnert, Ingo
AU  - Daehnert I
FAU - Kostelka, Martin
AU  - Kostelka M
FAU - Gutberlet, Matthias
AU  - Gutberlet M
FAU - Grothoff, Matthias
AU  - Grothoff M
LA  - eng
PT  - Journal Article
DEP - 20130202
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Cicatrix/*etiology/pathology/physiopathology
MH  - Congenitally Corrected Transposition of the Great Arteries
MH  - *Contrast Media
MH  - Female
MH  - Heart Failure/*etiology/pathology/physiopathology
MH  - Heart Ventricles/*abnormalities/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Myocardium/*pathology
MH  - *Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Transposition of Great Vessels/*complications/pathology/physiopathology/surgery
MH  - Ventricular Dysfunction, Right/*etiology/pathology/physiopathology
MH  - Ventricular Function, Right
MH  - Young Adult
EDAT- 2013/02/05 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/06/08 00:00 [received]
PHST- 2013/01/22 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1007/s00392-013-0539-4 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2013 May;102(5):337-44. doi: 10.1007/s00392-013-0539-4. Epub 
      2013 Feb 2.