PMID- 23378146
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20220129
IS  - 1557-0681 (Electronic)
IS  - 1478-2189 (Linking)
VI  - 11
IP  - 4
DP  - 2013 Dec
TI  - Different wording of the Patient Global Visual Analogue Scale (PG-VAS) affects 
      rheumatoid arthritis patients' scoring and the overall Disease Activity Score 
      (DAS28): a cross-sectional study.
PG  - 229-37
LID - 10.1002/msc.1046 [doi]
AB  - OBJECTIVE: The Disease Activity Score in 28 joints (DAS28) is a key measure in 
      clinical practice and clinical trials. There are at least five different versions 
      of the 'Patient Global' Visual Analogue Scale (PG-VAS) being used in the DAS28. 
      The developers suggested that the PG-VAS can be an assessment of global health or 
      disease activity, but did not specify the wording of the question. There is no 
      consensus on what the PG-VAS is intended to capture, and the different words and 
      phrases have not been evaluated. The aim of this study was to test if phrasing 
      affects PG-VAS scores and hence yields different results for the DAS28. METHODS: 
      Fifty patients with rheumatoid arthritis taking biologic agents in a rheumatology 
      outpatient department completed a self-administered questionnaire containing five 
      versions of the 100 mm PG-VAS. RESULTS: All PG-VAS versions correlated strongly 
      with each other (rho = 0.67-0.87, p < 0.0001). However, individual scores for 
      each PG-VAS, when compared with the comparator on a Bland-Altman chart had wide 
      limits of agreement--the largest being -42 mm to +45 mm. The five overall DAS28 
      scores were calculated for each patient using the five different PG-VAS. The 
      largest difference in DAS28 scores was 0.63. CONCLUSION: Different phrasing of 
      the PG-VAS gives different DAS28 results. As the DAS28 is a key outcome measure, 
      such differences have the potential to influence clinical decisions relating to 
      eligibility for biologic agents and evaluation of new therapies. We urgently need 
      to decide on the concept to be measured and the phrasing required to capture 
      this. The PG-VAS phrasing should then be standardized and validated.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - French, Tracy
AU  - French T
AD  - Rheumatology Department, Bristol Royal Infirmary, Bristol, UK.
FAU - Hewlett, Sarah
AU  - Hewlett S
FAU - Kirwan, John
AU  - Kirwan J
FAU - Sanderson, Tessa
AU  - Sanderson T
LA  - eng
GR  - G0802695/MRC_/Medical Research Council/United Kingdom
GR  - 17974/ARC_/Arthritis Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130204
PL  - England
TA  - Musculoskeletal Care
JT  - Musculoskeletal care
JID - 101181344
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthralgia/*diagnosis/psychology/therapy
MH  - Arthritis, Rheumatoid/*diagnosis/psychology/therapy
MH  - Cross-Sectional Studies
MH  - Emotions
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Pain Measurement/*methods/*psychology
MH  - *Severity of Illness Index
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - DAS28
OT  - Rheumatoid arthritis
OT  - outcomes research
OT  - patient perspective
EDAT- 2013/02/05 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - 10.1002/msc.1046 [doi]
PST - ppublish
SO  - Musculoskeletal Care. 2013 Dec;11(4):229-37. doi: 10.1002/msc.1046. Epub 2013 Feb 
      4.