PMID- 23380141
OWN - NLM
STAT- MEDLINE
DCOM- 20131025
LR  - 20131121
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 5
DP  - 2013 May
TI  - Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever.
PG  - 610-7
LID - S0198-8859(13)00038-4 [pii]
LID - 10.1016/j.humimm.2013.01.027 [doi]
AB  - Genes coding for human leukocyte antigen (HLA) class II molecules and tumor 
      necrosis factor (TNF)-alpha are polymorphic and have been shown to influence 
      susceptibility to infectious diseases. In the present study, HLA-DRB1, -DQB1 and 
      TNF gene polymorphisms were investigated in 114 dengue patients (DEN) [85 dengue 
      fever (DF) cases and 29 dengue hemorrhagic fever (DHF) cases] and 110 healthy 
      controls (HCs) using PCR based methods. The frequencies of HLA-DRB1*07 allele [DF 
      vs. DHF, P=0.0034, Pc=0.044, OR 3.79] and HLA-DRB1*07/*15 genotype [DF vs. DHF, 
      P=0.00071, Pc=0.038, OR 10.41] were significantly higher in DHF cases as compared 
      to HCs and DF cases. Higher frequency of rs1800629 'G/A' genotype was observed in 
      DHF cases as compared to DF cases. The frequency of rs1799964 'C/C' genotype of 
      the TNF gene was found to be significantly higher in all patient groups compared 
      to HCs [HCs vs. DEN, P=0.0054, Pc=0.0162, OR 3.57; HCs vs. DF, P=0.036, OR 2.89; 
      HCs vs. DHF, P=0.0088, Pc=0.0240, OR 5.11]. Presence of combination of 
      HLA-DRB1*07/*15 with either rs1799964 'C/C' genotype or rs1800629 'G/A' genotype 
      or both was present in 17.2% of DHF cases and 1.2% in HCs while this combination 
      was not observed in DF cases. The results suggest that HLA-DRB1*07/*15 genotype 
      in combination with TNF polymorphisms influence progression to DHF.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Alagarasu, K
AU  - Alagarasu K
AD  - Dengue Group, National Institute of Virology, 20 A Dr. Ambedkar Road, Pune, 
      Maharashtra, India. alagarasu@gmail.com
FAU - Mulay, A P
AU  - Mulay AP
FAU - Singh, R
AU  - Singh R
FAU - Gavade, V B
AU  - Gavade VB
FAU - Shah, P S
AU  - Shah PS
FAU - Cecilia, D
AU  - Cecilia D
LA  - eng
PT  - Journal Article
DEP - 20130201
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Severe Dengue/*genetics/pathology
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
EDAT- 2013/02/06 06:00
MHDA- 2013/10/26 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/11/15 00:00 [received]
PHST- 2012/12/31 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/10/26 06:00 [medline]
AID - S0198-8859(13)00038-4 [pii]
AID - 10.1016/j.humimm.2013.01.027 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 May;74(5):610-7. doi: 10.1016/j.humimm.2013.01.027. Epub 2013 
      Feb 1.