PMID- 23380142
OWN - NLM
STAT- MEDLINE
DCOM- 20131025
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 5
DP  - 2013 May
TI  - Effect of human leukocyte antigen class II genes on Hashimoto's thyroiditis 
      requiring replacement therapy with levothyroxine in the Japanese population.
PG  - 607-9
LID - S0198-8859(13)00037-2 [pii]
LID - 10.1016/j.humimm.2013.01.026 [doi]
AB  - Contribution of the human leukocyte antigen (HLA) subtype to Hashimoto's 
      thyroiditis (HT) that requires replacement therapy with levothyroxine remains 
      unclear in the Japanese population. The frequencies of HLA DR-DQ haplotypes were 
      compared between patients with HT requiring levothyroxine replacement therapy and 
      the control individuals. We studied 82 patients with HT requiring levothyroxine 
      replacement therapy. The frequencies of DRB1*08:03-DQB1*06:01 and 
      DRB1*09:01-DQB1*03:03 haplotypes were significantly higher in HT patients, 
      whereas those of DRB1*13:02-DQB1*06:04 and DRB1*15:01-DQB1*06:02 haplotypes were 
      significantly lower in these patients than in the controls. Deduced from known 
      linkage disequilibria, DRB1*13:02-DQB1*06:04 and DRB1*15:01-DQB1*06:02 haplotypes 
      share the same DQA1*01:02 allele. Since DQB1*06:02 and DQB1*06:04 molecules 
      differ in the beta chain by 7 residues, these DQB1 genes are very similar. The 
      DQA1*01:02-DQB1*06 (DQB1*06:02 or DQB1*06:04) haplotype might play a pivotal role 
      in the resistance to HT.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Katahira, Masahito
AU  - Katahira M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan. katahira-0034@umin.net
FAU - Hanakita, Mizuki
AU  - Hanakita M
FAU - Ito, Tatsuo
AU  - Ito T
FAU - Suzuki, Mari
AU  - Suzuki M
LA  - eng
PT  - Journal Article
DEP - 20130201
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ alpha-Chains/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Hormone Replacement Therapy/*methods
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Thyroiditis, Autoimmune/*drug therapy/ethnology/*genetics
MH  - Thyroxine/*therapeutic use
MH  - Young Adult
EDAT- 2013/02/06 06:00
MHDA- 2013/10/26 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/10/25 00:00 [received]
PHST- 2012/12/18 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/10/26 06:00 [medline]
AID - S0198-8859(13)00037-2 [pii]
AID - 10.1016/j.humimm.2013.01.026 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 May;74(5):607-9. doi: 10.1016/j.humimm.2013.01.026. Epub 2013 
      Feb 1.