PMID- 23380296
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20131121
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 29
IP  - 9
DP  - 2013 Sep
TI  - Late gadolinium enhancement in cardiac transplant patients is associated with 
      adverse ventricular functional parameters and clinical outcomes.
PG  - 1076-83
LID - S0828-282X(12)01426-2 [pii]
LID - 10.1016/j.cjca.2012.10.021 [doi]
AB  - BACKGROUND: Heart transplant recipients (HTRs) experience multiple cardiac 
      complications, many of which might produce myocardial fibrosis. Cardiovascular 
      magnetic resonance imaging (CMR) can image myocardial fibrosis using late 
      gadolinium enhancement (LGE) imaging. We hypothesized that the presence and 
      volume of LGE in heart transplant recipients correlates with left ventricular 
      (LV) functional parameters and clinical outcomes. METHODS: Thirty-eight stable 
      HTRs underwent a CMR study and clinical follow-up. RESULTS: In 38 stable HTRs, 
      LGE was seen in 19 patients (50%), of which 15 (79%) had a nonischemic pattern 
      and 4 (21%) had an ischemic pattern. LGE volume was associated with reduced LV 
      ejection fraction (EF) (R(2) = 0.57; P = 0.001) and increased LV end-diastolic 
      volume (R(2) = 0.59; P = 0.001). The presence of LGE was associated with 
      cardiovascular death or hospitalization within the next year (P = 0.04), and 
      patients who died or were hospitalized had more LGE than those that were not 
      hospitalized (15 g vs 7 g; P = 0.03). CONCLUSIONS: LGE is common in HTR and is 
      associated with adverse ventricular remodelling and adverse clinical outcomes. 
      LGE might be a useful noninvasive approach to monitor graft disease in 
      asymptomatic patients after heart transplant.
CI  - Copyright (c) 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Butler, Craig R
AU  - Butler CR
AD  - Division of Cardiology, Mazankowski Alberta Heart Institute, Edmonton, Alberta, 
      Canada. crbutler@ualberta.ca
FAU - Kumar, Andreas
AU  - Kumar A
FAU - Toma, Mustafa
AU  - Toma M
FAU - Thompson, Richard
AU  - Thompson R
FAU - Chow, Kelvin
AU  - Chow K
FAU - Isaac, Debra
AU  - Isaac D
FAU - Kim, Daniel
AU  - Kim D
FAU - Haykowsky, Mark
AU  - Haykowsky M
FAU - Friedrich, Matthias G
AU  - Friedrich MG
FAU - Paterson, Ian
AU  - Paterson I
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130204
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media/*adverse effects
MH  - Death
MH  - Female
MH  - Fibrosis
MH  - Follow-Up Studies
MH  - Gadolinium DTPA/*adverse effects
MH  - *Heart Transplantation
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Postoperative Complications
MH  - Prognosis
MH  - Stroke Volume/drug effects
MH  - Ventricular Dysfunction, Left/*chemically induced/physiopathology
MH  - Ventricular Remodeling/drug effects
EDAT- 2013/02/06 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/08/09 00:00 [received]
PHST- 2012/10/23 00:00 [revised]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - S0828-282X(12)01426-2 [pii]
AID - 10.1016/j.cjca.2012.10.021 [doi]
PST - ppublish
SO  - Can J Cardiol. 2013 Sep;29(9):1076-83. doi: 10.1016/j.cjca.2012.10.021. Epub 2013 
      Feb 4.