PMID- 23380505
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130415
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Steroid hormones and BDNF.
PG  - 271-9
LID - S0306-4522(13)00062-6 [pii]
LID - 10.1016/j.neuroscience.2013.01.025 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophin abundantly expressed 
      in several areas of the central nervous system (CNS) and is known to induce a 
      lasting potentiation of synaptic efficacy, to enhance specific learning and 
      memory processes. BDNF is one of the key molecules modulating brain plasticity 
      and it affects cognitive deficit associated with aging and neurodegenerative 
      disease. Several studies have shown an altered BDNF production and secretion in a 
      variety of neurodegenerative diseases like Alzheimer's and Parkinson's diseases 
      but also in mood disorders like depression, eating disorders and schizophrenia. 
      Plasma BDNF is also a biomarker of impaired memory and general cognitive function 
      in aging women. Gonadal steroids are involved in the regulation of several CNS 
      processes, specifically mood, affective and cognitive functions during fertile 
      life and reproductive aging. These observations lead many scientists to 
      investigate a putative co-regulation between BDNF and gonadal and/or adrenal 
      steroids and their relationship with gender difference in the incidence of mental 
      diseases. This overview aims to summarize the current knowledge on the 
      correlation between BDNF expression/function and both gonadal (progesterone, 
      estrogens, and testosterone) and adrenal hormones (mainly cortisol and 
      dehydroepiandrosterone (DHEA)) with relevance in clinical application.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Pluchino, N
AU  - Pluchino N
AD  - Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy.
FAU - Russo, M
AU  - Russo M
FAU - Santoro, A N
AU  - Santoro AN
FAU - Litta, P
AU  - Litta P
FAU - Cela, V
AU  - Cela V
FAU - Genazzani, A R
AU  - Genazzani AR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130201
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Humans
EDAT- 2013/02/06 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/07/15 00:00 [received]
PHST- 2012/12/29 00:00 [revised]
PHST- 2013/01/09 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(13)00062-6 [pii]
AID - 10.1016/j.neuroscience.2013.01.025 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:271-9. doi: 10.1016/j.neuroscience.2013.01.025. Epub 
      2013 Feb 1.