PMID- 23380506 OWN - NLM STAT- MEDLINE DCOM- 20130930 LR - 20220310 IS - 1768-3122 (Electronic) IS - 0248-8663 (Linking) VI - 34 IP - 4 DP - 2013 Apr TI - [Management of angiotensin-converting enzyme inhibitor-related angioedema: recommendations from the French National Center for Angioedema]. PG - 209-13 LID - S0248-8663(12)01195-2 [pii] LID - 10.1016/j.revmed.2012.12.017 [doi] AB - Angiotensin-converting enzyme (ACE) inhibitor-related angioedema (AE) may be fatal in the absence of specific treatment. No consensus for this side effect currently exists. Also, the French national reference centre for angioedema (CREAK) decided to establish recommendations, developed by an expert group and proposed at a national meeting. A scientific committee conducted a comprehensive literature review and worked out with proposals. These proposals were submitted to a vote to the expert panel of CREAK at a national meeting. Proposals that had received the majority were retained. Diagnosis of ACE inhibitor-related AE is based on clinical events. Regarding the severity of the disease, this diagnosis has to be put forward in any patient currently treated with or who has been treated with ACE inhibitors in the previous 6 months. The diagnosis is important because AE does not respond to usual treatment of histamine-induced AE (antihistamines, corticosteroids, and epinephrine), but only to specific treatment of bradykinin-induced AE, as antagonists of bradykinin or concentrates of C1 inhibitor. The subsequent use of ACE is strictly contra-indicated. A report to pharmacovigilance centres of every case is essential. These recommendations should improve the standardization of the management of ACE inhibitor-related AE. CI - Copyright (c) 2013 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier SAS. All rights reserved. FAU - Nosbaum, A AU - Nosbaum A AD - Allergologie et immunologie clinique, centre hospitalier Lyon-Sud, hospices civils de Lyon, 69495 Pierre-Benite, France. FAU - Bouillet, L AU - Bouillet L FAU - Floccard, B AU - Floccard B FAU - Javaud, N AU - Javaud N FAU - Launay, D AU - Launay D FAU - Boccon-Gibod, I AU - Boccon-Gibod I FAU - Fain, O AU - Fain O CN - Groupe d'experts du CREAK CN - French National Center for Angioedema LA - fre PT - English Abstract PT - Journal Article PT - Practice Guideline PT - Review TT - Prise en charge des angioedemes induits par les inhibiteurs de l'enzyme de conversion de l'angiotensine : recommandations du Centre de reference national des angioedemes. DEP - 20130204 PL - France TA - Rev Med Interne JT - La Revue de medecine interne JID - 8101383 RN - 0 (Adrenergic beta-Antagonists) RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 0 (Bradykinin Receptor Antagonists) RN - 0 (Dipeptidyl-Peptidase IV Inhibitors) RN - 0 (Immunosuppressive Agents) RN - 7PG89G35Q7 (icatibant) RN - S8TIM42R2W (Bradykinin) SB - IM MH - Adrenergic beta-Antagonists/therapeutic use MH - Angioedema/*chemically induced/diagnosis/*drug therapy MH - Angiotensin Receptor Antagonists/therapeutic use MH - Angiotensin-Converting Enzyme Inhibitors/*adverse effects MH - Bradykinin/analogs & derivatives/metabolism/therapeutic use MH - Bradykinin Receptor Antagonists MH - Dipeptidyl-Peptidase IV Inhibitors/adverse effects MH - France MH - Humans MH - Immunosuppressive Agents/adverse effects EDAT- 2013/02/06 06:00 MHDA- 2013/10/01 06:00 CRDT- 2013/02/06 06:00 PHST- 2012/12/10 00:00 [received] PHST- 2012/12/20 00:00 [accepted] PHST- 2013/02/06 06:00 [entrez] PHST- 2013/02/06 06:00 [pubmed] PHST- 2013/10/01 06:00 [medline] AID - S0248-8663(12)01195-2 [pii] AID - 10.1016/j.revmed.2012.12.017 [doi] PST - ppublish SO - Rev Med Interne. 2013 Apr;34(4):209-13. doi: 10.1016/j.revmed.2012.12.017. Epub 2013 Feb 4.