PMID- 23380525
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20131121
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 105
DP  - 2013 Apr
TI  - Prior MDMA exposure inhibits learning and produces both tolerance and 
      sensitization in the radial-arm maze.
PG  - 34-40
LID - S0091-3057(13)00022-1 [pii]
LID - 10.1016/j.pbb.2013.01.018 [doi]
AB  - Recent research using the partially-baited radial arm maze with rats has shown 
      that acute or single-session high-dose exposure to 
      +/-3,4-methylenedioxymethaphemtamine (MDMA) impairs reference memory processes 
      more so than working memory processes. The current study examined the effect that 
      an initial binge exposure of MDMA had on the ability to learn this task and 
      whether such exposure produced tolerance or sensitization to subsequent low dose 
      acute MDMA exposure. Following either an initial binge dose (4x10mg/kg) of MDMA 
      or saline, rats received regular weekly injections of either MDMA (4.0mg/kg) or 
      saline during task acquisition training. Although eventually able to acquire the 
      task at a level comparable to controls, initial binge MDMA exposure significantly 
      impaired task acquisition. Binge-treated rats displayed evidence of a tolerance 
      effect to subsequent acute injections of MDMA; although with continued training 
      this tolerance effect was reduced. However, initial binge treatment also produced 
      a sensitized response to subsequent acute MDMA exposure that manifested as a 
      prolonged period of impairment up to 24h following administration. Consistent 
      with the effects seen following other regimes of exposure to MDMA, the pattern of 
      errors made was best described as an impairment to reference memory processes as 
      opposed to working memory processes.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Harper, D N
AU  - Harper DN
AD  - Victoria University of Wellington, New Zealand. david.harper@vuw.ac.nz
FAU - Kay, C
AU  - Kay C
FAU - Hunt, M
AU  - Hunt M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130201
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adaptation, Physiological/*drug effects
MH  - Animals
MH  - Learning/*drug effects
MH  - Male
MH  - *Maze Learning
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2013/02/06 06:00
MHDA- 2013/10/24 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/10/21 00:00 [received]
PHST- 2013/01/09 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - S0091-3057(13)00022-1 [pii]
AID - 10.1016/j.pbb.2013.01.018 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2013 Apr;105:34-40. doi: 10.1016/j.pbb.2013.01.018. Epub 
      2013 Feb 1.