PMID- 23380586
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20211021
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 256
IP  - 1-2
DP  - 2013 Mar 15
TI  - Systemic immune system alterations in early stages of Alzheimer's disease.
PG  - 38-42
LID - S0165-5728(13)00004-0 [pii]
LID - 10.1016/j.jneuroim.2013.01.002 [doi]
AB  - Immune activation and inflammation play significant roles in the pathogenesis of 
      Alzheimer's disease (AD). To test whether AD patients showed systemic 
      manifestations of inflammation, blood from 41 patients with early stages of AD 
      and 31 aged-match elderly controls were evaluated. Cellular markers for 
      monocyte/macrophage (MO) activation and CD8 T lymphocyte were increased in early 
      AD patients. Expression of monocyte CCR2, the receptor for monocyte 
      chemoattractant protein-1 (MCP-1), was decreased; however, plasma MCP-1 levels 
      were significantly increased and were related to the degree of MO activation in 
      AD. These findings suggest that AD pathogenesis may be influenced by systemic 
      immunologic dysfunction and provides potential immunologic targets for 
      therapeutic intervention.
CI  - Published by Elsevier B.V.
FAU - Zhang, Rongzhen
AU  - Zhang R
AD  - University of California, San Francisco, San Francisco, CA 94110, USA.
FAU - Miller, Robert G
AU  - Miller RG
FAU - Madison, Catherine
AU  - Madison C
FAU - Jin, Xia
AU  - Jin X
FAU - Honrada, Ronald
AU  - Honrada R
FAU - Harris, Will
AU  - Harris W
FAU - Katz, Jonathan
AU  - Katz J
FAU - Forshew, Dallas A
AU  - Forshew DA
FAU - McGrath, Michael S
AU  - McGrath MS
LA  - eng
GR  - U01 CA066529/CA/NCI NIH HHS/United States
GR  - U01-CA 66529/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130204
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*immunology/*physiopathology
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Cross-Sectional Studies
MH  - Cytokines/blood
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immune System/*metabolism
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Macrophage Activation
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism
PMC - PMC3641776
MID - NIHMS442008
EDAT- 2013/02/06 06:00
MHDA- 2013/04/16 06:00
PMCR- 2014/03/15
CRDT- 2013/02/06 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/12/28 00:00 [revised]
PHST- 2013/01/02 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
PHST- 2014/03/15 00:00 [pmc-release]
AID - S0165-5728(13)00004-0 [pii]
AID - 10.1016/j.jneuroim.2013.01.002 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2013 Mar 15;256(1-2):38-42. doi: 10.1016/j.jneuroim.2013.01.002. 
      Epub 2013 Feb 4.