PMID- 2338131
OWN - NLM
STAT- MEDLINE
DCOM- 19900618
LR  - 20071115
IS  - 0301-472X (Print)
IS  - 0301-472X (Linking)
VI  - 18
IP  - 5
DP  - 1990 Jun
TI  - Bone marrow transplantation for chronic myeloid leukemia: the use of 
      histocompatible unrelated volunteer donors.
PG  - 421-5
AB  - We treated 17 patients with chronic myeloid leukemia (CML) by bone marrow 
      transplantation using marrow from human leukocyte antigen (HLA)-matched unrelated 
      donors. Patients were conditioned with a combination of in vivo monoclonal 
      antibodies, chemotherapy with daunorubicin (n = 7) or busulfan (n = 10) and 
      cyclophosphamide, and both total body and total lymphoid irradiation. Donor 
      marrow was depleted of T cells by incubation with monoclonal antibodies of the 
      Campath series. Fourteen (88%) of 16 evaluable patients had sustained 
      engraftment. Four (27%) of the 15 evaluable patients developed acute 
      graft-versus-host disease (GVHD) of grade II or greater, and 4 of 12 evaluable 
      patients developed chronic GVHD. Three patients developed hematological and two 
      developed cytogenetic evidence of relapse. Eight patients (47%) survive at a 
      median follow-up of 32 months (range 10-51 months), giving an actuarial survival 
      of 44%. Five patients remain alive without evidence of hematological or 
      cytogenetic relapse, giving an actuarial disease-free survival of 27%. 
      Pneumonitis caused or contributed to death in six of the nine patients who died. 
      We conclude that T-cell depletion can prevent the severest forms of GVHD but also 
      increases the risk of relapse after transplant with unrelated donors, as it does 
      with HLA-identical siblings. Nevertheless the use of matched unrelated donors 
      should be considered for CML patients who lack HLA-identical siblings.
FAU - Mackinnon, S
AU  - Mackinnon S
AD  - MRC/LRF Leukaemia Unit, Royal Postgraduate Medical School, London, UK.
FAU - Hows, J M
AU  - Hows JM
FAU - Goldman, J M
AU  - Goldman JM
FAU - Arthur, C K
AU  - Arthur CK
FAU - Hughes, T
AU  - Hughes T
FAU - Apperley, J F
AU  - Apperley JF
FAU - Jones, L
AU  - Jones L
FAU - Batchelor, J R
AU  - Batchelor JR
FAU - Brookes, P
AU  - Brookes P
FAU - Catovsky, D
AU  - Catovsky D
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Exp Hematol
JT  - Experimental hematology
JID - 0402313
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Graft vs Host Disease
MH  - HLA Antigens/analysis
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
PST - ppublish
SO  - Exp Hematol. 1990 Jun;18(5):421-5.