PMID- 23382403
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20221207
IS  - 1941-7225 (Electronic)
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Feb
TI  - Analysis of sex hormone genes reveals gender differences in the genetic etiology 
      of blood pressure salt sensitivity: the GenSalt study.
PG  - 191-200
LID - 10.1093/ajh/hps018 [doi]
AB  - BACKGROUND: We examined the association between 799 single-nucleotide 
      polymorphisms in 39 sex hormone genes and blood pressure (BP) responses to a 
      dietary-sodium intervention. METHODS: A 7-day low-sodium feeding study (51.3 mmol 
      sodium/day) followed by a 7-day high-sodium feeding study (307.8 mmol sodium/day) 
      was conducted among 1,906 Han Chinese participants. Nine BP measurements were 
      obtained at baseline and the end of each intervention period using a random-zero 
      sphygmomanometer. RESULTS: Among men, absolute BP responses to sodium 
      interventions decreased with the number of minor alleles of estrogen receptor 1 
      (ESR1) markers rs9340844, rs9397453, rs9371562, rs9397459, and rs9383951. For 
      example, mean diastolic blood pressure (DBP) responses to low-sodium intervention 
      (95% confidence interval) were -2.67 (-3.13, -2.22) mm Hg among those with the 
      rs9397453 C/C genotype, -1.23 (-1.98, -0.48) mm Hg among those with the C/T 
      genotype, and 0.08 (-2.31, 2.47) mm Hg among those with the T/T genotype (P = 
      1x10(-4); false discovery rate (FDR)-q = 0.04). Mean DBP responses to high sodium 
      according to the rs9397453 genotypes were 1.46 (1.03, 1.89) mm Hg among those 
      with C/C, 0.19 (-0.54, 0.91) mm Hg among those with C/T, and -1.10 (-2.82, 0.61) 
      mm Hg among those with T/T (P = 2x10(-4); FDR-q = 0.04). Similar trends were 
      noted for the association between these ESR1 variants and SBP responses to the 
      dietary intervention. There were no significant associations between sex hormone 
      gene variants and salt sensitivity in women, with genotype-gender interactions 
      noted for the ESR1 markers that achieved significance in men. CONCLUSIONS: We 
      identified strong, consistent associations between ESR1 gene variants and salt 
      sensitivity in men. Our results support a gender-specific role for ESR1 in the 
      etiology of this complex trait.
FAU - Kelly, Tanika N
AU  - Kelly TN
AD  - Department of Epidemiology, Tulane University School of Public Health and 
      Tropical Medicine, New Orleans, LA, USA. tkelly@tulane.edu
FAU - Rebholz, Casey M
AU  - Rebholz CM
FAU - Gu, Dongfeng
AU  - Gu D
FAU - Hixson, James E
AU  - Hixson JE
FAU - Rice, Treva K
AU  - Rice TK
FAU - Cao, Jie
AU  - Cao J
FAU - Chen, Jichun
AU  - Chen J
FAU - Li, Jianxin
AU  - Li J
FAU - Lu, Fanghong
AU  - Lu F
FAU - Ma, Jixiang
AU  - Ma J
FAU - Mu, Jianjun
AU  - Mu J
FAU - Whelton, Paul K
AU  - Whelton PK
FAU - He, Jiang
AU  - He J
LA  - eng
SI  - ClinicalTrials.gov/NCT00721721
GR  - R01HL087263/HL/NHLBI NIH HHS/United States
GR  - R01HL090682/HL/NHLBI NIH HHS/United States
GR  - K12 HD043451/HD/NICHD NIH HHS/United States
GR  - K12HD043451/HD/NICHD NIH HHS/United States
GR  - U01HL072507/HL/NHLBI NIH HHS/United States
GR  - R01 HL090682/HL/NHLBI NIH HHS/United States
GR  - R01 HL087263/HL/NHLBI NIH HHS/United States
GR  - U01 HL072507/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121228
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Sodium Chloride, Dietary)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/ethnology/*genetics
MH  - Blood Pressure/*genetics
MH  - China
MH  - Estrogen Receptor alpha/genetics
MH  - Female
MH  - *Genes
MH  - Genetic Predisposition to Disease/ethnology/genetics
MH  - Genotype
MH  - Gonadal Steroid Hormones/*genetics
MH  - Humans
MH  - Hypertension/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Sex Characteristics
MH  - Sex Factors
MH  - Sodium Chloride, Dietary/*adverse effects
PMC - PMC3626038
EDAT- 2013/02/06 06:00
MHDA- 2013/08/31 06:00
PMCR- 2014/02/01
CRDT- 2013/02/06 06:00
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - hps018 [pii]
AID - 10.1093/ajh/hps018 [doi]
PST - ppublish
SO  - Am J Hypertens. 2013 Feb;26(2):191-200. doi: 10.1093/ajh/hps018. Epub 2012 Dec 
      28.