PMID- 23385080
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20191210
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 257
IP  - 1-2
DP  - 2013 Apr 15
TI  - Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by 
      herpes simplex virus type 1.
PG  - 7-12
LID - S0165-5728(13)00008-8 [pii]
LID - 10.1016/j.jneuroim.2013.01.005 [doi]
AB  - Intravenous immunoglobulin (IVIG) treatment of Alzheimer's disease (AD) has been 
      encouraging. Its mechanism of action might be via anti-beta-amyloid (Abeta) antibodies 
      which facilitate Abeta clearance. However, IVIG's benefits might result from its 
      antiviral activity, particularly against herpes simplex virus type 1 (HSV1), a 
      virus implicated in AD. We investigated IVIG's effect on HSV1, specifically on 
      the accumulation of Abeta and abnormally phosphorylated tau which it causes. We show 
      that IVIG is effective at reducing the accumulation of these abnormal molecules 
      and that it acts synergistically with the antiviral acyclovir, suggesting that 
      their combined use would be beneficial for treating AD.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Wozniak, Matthew A
AU  - Wozniak MA
AD  - Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK.
FAU - Itzhaki, Ruth F
AU  - Itzhaki RF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130204
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Viral Structural Proteins)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Amyloid beta-Peptides/adverse effects/*antagonists & inhibitors/*metabolism
MH  - Animals
MH  - Chlorocebus aethiops
MH  - Herpesvirus 1, Human/*pathogenicity
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Vero Cells
MH  - Viral Structural Proteins/antagonists & inhibitors/biosynthesis
MH  - tau Proteins/adverse effects/*antagonists & inhibitors/biosynthesis
EDAT- 2013/02/07 06:00
MHDA- 2013/05/23 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2013/01/07 00:00 [revised]
PHST- 2013/01/10 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0165-5728(13)00008-8 [pii]
AID - 10.1016/j.jneuroim.2013.01.005 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2013 Apr 15;257(1-2):7-12. doi: 10.1016/j.jneuroim.2013.01.005. 
      Epub 2013 Feb 4.