PMID- 23386252
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20211021
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Aug
TI  - Prognostic study of sevoflurane-based general anesthesia on cognitive function in 
      children.
PG  - 493-9
LID - 10.1007/s00540-013-1566-z [doi]
AB  - PURPOSE: It is unclear whether volatile general anesthetics have sustained 
      adverse effects on the immature brains of children. We performed a 
      self-controlled study to evaluate the effects of strabismus surgery under 
      sevoflurane-based general anesthesia on the cognitive function of pediatric 
      patients. METHODS: The study included 100 children of ages 4 to 7 years old 
      scheduled to undergo strabismus correction under sevoflurane-based general 
      anesthesia. Cognitive function was tested 1 day before the operation (T1), 1 
      month after the operation (T2), and 6 months after the operation by the Wechsler 
      Preschool and Primary Scale of Intelligence (WPPSI) (Third Edition) method, which 
      consists of 150 items. The scores at T1 were compared with scores at T2 and T3. 
      RESULTS: Seventy-two children completed the three tests. At T1, they were 66.1 +/- 
      7.7 months old and had a mean body weight of 21.6 +/- 4.0 kg. The mean anesthesia 
      time was 67.3 +/- 9.8 min. The mean interval between T1 and T2 was 25.4 +/- 6.8 days, 
      and that between T1 and T3 was 182.1 +/- 27.7 days. No statistically significant 
      decrease in WPPSI scores was observed between T1 and T2, or between T1 and T3. 
      CONCLUSION: These findings from our self-controlled study show that 
      sevoflurane-based general anesthesia does not have significantly adverse effects 
      on the cognitive function of 4- to 7-year-old children at 1 month and 6 months 
      after strabismus surgery. Additional studies with a larger sample size are 
      needed.
FAU - Fan, Qing
AU  - Fan Q
AD  - Department of Anesthesiology, Eye & ENT Hospital of Fudan University, 83 Fenyang 
      Rd, Xuhui District, Shanghai, 200031, China.
FAU - Cai, Yirong
AU  - Cai Y
FAU - Chen, Kaizheng
AU  - Chen K
FAU - Li, Wenxian
AU  - Li W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130206
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Anesthesia, General/*adverse effects
MH  - Anesthesia, Inhalation/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Cognition/*drug effects
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Methyl Ethers/administration & dosage/*adverse effects
MH  - Sevoflurane
MH  - Strabismus/surgery
EDAT- 2013/02/07 06:00
MHDA- 2014/05/20 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2013/01/21 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
AID - 10.1007/s00540-013-1566-z [doi]
PST - ppublish
SO  - J Anesth. 2013 Aug;27(4):493-9. doi: 10.1007/s00540-013-1566-z. Epub 2013 Feb 6.