PMID- 23386255
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 102
IP  - 5
DP  - 2013 May
TI  - Autonomic involvement in idiopathic premature ventricular contractions.
PG  - 361-70
LID - 10.1007/s00392-013-0545-6 [doi]
AB  - OBJECTIVE: To investigate autonomic involvement in different types of idiopathic 
      premature ventricular contractions (PVCs) grouped by heart rate (HR) dependency. 
      METHODS: One hundred and sixty PVC patients and 31 controls were enrolled. Holter 
      ECG was used to evaluate PVC occurrence, and spectral analysis of heart rate 
      variability (HRV) was calculated to represent cardiac autonomic control. PVCs 
      were divided into fast rate-dependent (F-PVC), slow rate-dependent (S-PVC), and 
      HR-independent PVC (I-PVC) based on the relationship between hourly PVC density 
      and hourly HR. HRV among different types of PVCs were compared, and the 
      association between PVC density with HR and HRV were analyzed. Furthermore, 
      autonomic changes assessed by consecutive 5-min HRV in 30 min before PVC episodes 
      were investigated. RESULTS: In 160 subjects, there were 73 F-PVC, 56 S-PVC, and 
      31 I-PVC. Hourly PVC density was positively associated with sympathetic indice 
      (LF/HF) and negatively related to vagal indices (HF and HFnu) in F-PVC, and this 
      trend was reversed in S-PVC. During 30 min before PVC onset, RR interval and HFnu 
      decreased significantly with LF/HF showing an increasing trend in F-PVC, while in 
      S-PVC both RR interval and HF increased significantly. It was noted that those 
      changes were most evident during the last 5 min before PVC onset. In addition, 
      PVC density in F-PVC was significantly decreased by beta-blocker treatment. 
      CONCLUSIONS: HR dependency reflected autonomic modulation of idiopathic PVCs. 
      F-PVC and S-PVC might be facilitated by sympathetic activation and vagal 
      activation, respectively. HR dependency and the related autonomic mechanisms 
      should be considered when treating idiopathic PVCs.
FAU - He, Wenbo
AU  - He W
AD  - Department of Cardiology, Renmin Hospital of Wuhan University and Cardiovascular 
      Research Institute of Wuhan University, 238 Jiefang Road, Wuchang 430060, Wuhan, 
      People's Republic of China.
FAU - Lu, Zhibing
AU  - Lu Z
FAU - Bao, Mingwei
AU  - Bao M
FAU - Yu, Lilei
AU  - Yu L
FAU - He, Bo
AU  - He B
FAU - Zhang, Yijie
AU  - Zhang Y
FAU - Hu, Xiaorong
AU  - Hu X
FAU - Cui, Bo
AU  - Cui B
FAU - Huang, Bing
AU  - Huang B
FAU - Jiang, Hong
AU  - Jiang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130206
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Circadian Rhythm
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart/*innervation
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Sympathetic Nervous System/*physiopathology
MH  - Time Factors
MH  - Vagus Nerve/*physiopathology
MH  - Ventricular Premature Complexes/diagnosis/*physiopathology
EDAT- 2013/02/07 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/08/18 00:00 [received]
PHST- 2013/01/23 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1007/s00392-013-0545-6 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2013 May;102(5):361-70. doi: 10.1007/s00392-013-0545-6. Epub 
      2013 Feb 6.