PMID- 23386312 OWN - NLM STAT- MEDLINE DCOM- 20131031 LR - 20190819 IS - 1347-4820 (Electronic) IS - 1346-9843 (Linking) VI - 77 IP - 5 DP - 2013 TI - Stress/rest circumferential strain in non-ischemia, ischemia, and infarction--quantification by 3 Tesla tagged magnetic resonance imaging. PG - 1235-41 AB - BACKGROUND: Adenosine triphosphate (ATP) induces relative hypoperfusion in significantly stenotic coronary arteries, but its effect on myocardial strain has not been used clinically for the detection of ischemia. The purpose of this study was to quantify ATP-stress-induced contractile impairment as altered myocardial strain in coronary artery disease (CAD) using tagged magnetic resonance (MR) and to evaluate its diagnostic capability in comparison with ATP-stress myocardial perfusion-MR. METHODS AND RESULTS: Tagged MR and perfusion-MR under ATP-stress and rest conditions and late gadolinium enhancement (LGE) MR imaging were performed in 22 patients with suspected CAD. The peak absolute value of the circumferential strain (C-strain) was measured in 12 segments. Myocardial segments were categorized as non-ischemic (n=201), ischemic (n=42), or infarcted (n=21) according to the perfusion-MR and LGE MR imaging results. The absolute C-strain was significantly greater under ATP-stress (19+/-13%) (mean+/-SD) than under at-rest (15+/-11%, P<0.001) conditions in non-ischemic segments. Conversely, the absolute C-strain was significantly lower under ATP-stress (10+/-13%) than under at-rest (16+/-6%, P<0.01) conditions in ischemic segments. Optimal cutoff values for stress C-strain (-17.5%) could successfully differentiate segments with ischemia or infarction from non-ischemic ones with a sensitivity of 86%, a specificity of 65%, and an area under the curve of 0.79. CONCLUSIONS: C-strain analysis using tagged MR could detect ATP-stress-induced contractile impairment in ischemic myocardium. FAU - Kido, Tomoyuki AU - Kido T AD - Department of Radiology, Ehime University Graduate School of Medicine, Toon, Japan. tomozo0421@gmail.com FAU - Nagao, Michinobu AU - Nagao M FAU - Kido, Teruhito AU - Kido T FAU - Kurata, Akira AU - Kurata A FAU - Miyagawa, Masao AU - Miyagawa M FAU - Ogimoto, Akiyoshi AU - Ogimoto A FAU - Mochizuki, Teruhito AU - Mochizuki T LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130206 PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 RN - 0 (Contrast Media) RN - 8L70Q75FXE (Adenosine Triphosphate) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - *Adenosine Triphosphate MH - Aged MH - Area Under Curve MH - Biomechanical Phenomena MH - Contrast Media MH - Coronary Stenosis/*diagnosis/physiopathology MH - Female MH - Gadolinium DTPA MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - *Myocardial Contraction MH - Myocardial Infarction/*diagnosis/physiopathology MH - Myocardial Ischemia/*diagnosis/physiopathology MH - Myocardial Perfusion Imaging/*methods MH - Predictive Value of Tests MH - Prospective Studies MH - ROC Curve MH - Stress, Mechanical MH - Time Factors EDAT- 2013/02/07 06:00 MHDA- 2013/11/01 06:00 CRDT- 2013/02/07 06:00 PHST- 2013/02/07 06:00 [entrez] PHST- 2013/02/07 06:00 [pubmed] PHST- 2013/11/01 06:00 [medline] AID - DN/JST.JSTAGE/circj/CJ-12-1106 [pii] AID - 10.1253/circj.cj-12-1106 [doi] PST - ppublish SO - Circ J. 2013;77(5):1235-41. doi: 10.1253/circj.cj-12-1106. Epub 2013 Feb 6.