PMID- 23386903
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 4
IP  - 1
DP  - 2013
TI  - Dendritic cells in the cancer microenvironment.
PG  - 36-44
LID - 10.7150/jca.5046 [doi]
AB  - The complexity of the tumor immunoenvironment is underscored by the emergence and 
      discovery of different subsets of immune effectors and regulatory cells. 
      Tumor-induced polarization of immune cell differentiation and function makes this 
      unique environment even more intricate and variable. Dendritic cells (DCs) 
      represent a special group of cells that display different phenotype and activity 
      at the tumor site and exhibit differential pro-tumorigenic and anti-tumorigenic 
      functions. DCs play a key role in inducing and maintaining the antitumor 
      immunity, but in the tumor environment their antigen-presenting function may be 
      lost or inefficient. DCs might be also polarized into 
      immunosuppressive/tolerogenic regulatory DCs, which limit activity of effector T 
      cells and support tumor growth and progression. Although various factors and 
      signaling pathways have been described to be responsible for abnormal functioning 
      of DCs in cancer, there are still no feasible therapeutic modalities available 
      for preventing or reversing DC malfunction in tumor-bearing hosts. Thus, better 
      understanding of DC immunobiology in cancer is pivotal for designing novel or 
      improved therapeutic approaches that will allow proper functioning of DCs in 
      patients with cancer.
FAU - Ma, Yang
AU  - Ma Y
AD  - 1. Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, 
      PA, USA;
FAU - Shurin, Galina V
AU  - Shurin GV
FAU - Peiyuan, Zhu
AU  - Peiyuan Z
FAU - Shurin, Michael R
AU  - Shurin MR
LA  - eng
GR  - R01 CA154369/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20121215
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC3564245
OTO - NOTNLM
OT  - dendritic cells
OT  - immunosuppression
OT  - regulatory dendritic cells
OT  - tumor escape.
OT  - tumor microenvironment
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2013/02/07 06:00
MHDA- 2013/02/07 06:01
PMCR- 2013/01/01
CRDT- 2013/02/07 06:00
PHST- 2012/10/24 00:00 [received]
PHST- 2012/12/01 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/02/07 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - jcav04p0036 [pii]
AID - 10.7150/jca.5046 [doi]
PST - ppublish
SO  - J Cancer. 2013;4(1):36-44. doi: 10.7150/jca.5046. Epub 2012 Dec 15.