PMID- 23387127
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20130207
IS  - 0015-5314 (Print)
IS  - 0015-5314 (Linking)
VI  - 105
IP  - 4
DP  - 2012 Dec
TI  - [The prevalance of herpesviruses in human apical periodontitis samples].
PG  - 135-40
AB  - Apical periodontitis is primarily initiated by the endodonto-patogen bacteria 
      spreading from the inflamed or necrotic pulp tissues to the periapical area. 
      Nevertheless, findings within the past years have established a pathogenic role 
      of human herpesviruses such as Epstein-Barr virus (EBV) and human cytomegalovirus 
      (HCMV) in periapical inflammations. The authors analysed the prevalence, activity 
      and disease association of EBV, HCMV and human herpesvirus 6 (HHV-6) in 40 apical 
      periodontitis samples and 40 healthy pulp controls. Based on the viral DNA 
      results, EBV (29/40) was the most frequent herpesvirus in apical periodontitis, 
      followed by HHV-6 (8/40) and HCMV (4/40). According to the mRNA results 
      approximately two-third of the EBV DNA-positive lesions had active EBV 
      infections. However, the HHV-6 and the HCMV infections seemed to be of latent 
      state. Our findings suggest that EBV and HHV-GB infections primarily occurred in 
      large sized and symptomatic periapical lesions. The co-occurrence of large lesion 
      size and active EBV infection was strongly associated (OR = 8.80) with the 
      symptomatic manifestation of apical periodontitis.
FAU - Hernadi, Katinka
AU  - Hernadi K
AD  - Debreceni Egyetem OEC, Orvosi Mikrobiologiai Intezet, Debrecen.
FAU - Szalmas, Anita
AU  - Szalmas A
FAU - Mogyorosi, Richard
AU  - Mogyorosi R
FAU - Czompa, Levente
AU  - Czompa L
FAU - Veress, Gyorgy
AU  - Veress G
FAU - Csoma, Eszter
AU  - Csoma E
FAU - Marton, Ildiko
AU  - Marton I
FAU - Konya, Jozsef
AU  - Konya J
LA  - hun
PT  - English Abstract
PT  - Journal Article
TT  - Herpeszvirusok elofordulasa human periodontitis apicalis mintakban.
PL  - Hungary
TA  - Fogorv Sz
JT  - Fogorvosi szemle
JID - 0374613
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Case-Control Studies
MH  - Cytomegalovirus/isolation & purification
MH  - Cytomegalovirus Infections/diagnosis
MH  - DNA, Viral/isolation & purification
MH  - Dental Pulp Necrosis/diagnosis/epidemiology/virology
MH  - Herpesviridae/genetics/*isolation & purification
MH  - Herpesviridae Infections/*diagnosis/*epidemiology/virology
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Logistic Models
MH  - Periapical Periodontitis/diagnosis/*epidemiology/*virology
MH  - Prevalence
MH  - Risk Factors
MH  - Roseolovirus Infections/diagnosis
EDAT- 2013/02/08 06:00
MHDA- 2013/02/28 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
PST - ppublish
SO  - Fogorv Sz. 2012 Dec;105(4):135-40.