PMID- 23387222
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181202
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 6
DP  - 2012 Nov
TI  - [Expression changes of BDNF in lung of rats subjected to brain ischemia].
PG  - 897-900
AB  - OBJECTIVE: To investigate the expression of brain-derived neurotrophic factor 
      (BDNF) in lung injury induced by brain ischemia in rats. METHODS: 46 adult SD 
      rats were assigned randomly to sham operation group and brain ischemia lung 
      injury group (BILI, n = 23 in each group). Rats were subjected brain ischemia and 
      allowed to survived 3 d. After performed neurological functional severe deficit 
      evaluation, lung edema was observed (n=5). The BDNF expression for its mRNA and 
      protein in lung tissues was determined by using ELISA (n=5) and RT-PCR technique 
      (n=8). The localization of BDNF was also determined by immunohistochemistry 
      (n=5). RESULTS: After brain ischemia for 3 days, the severe neurological 
      functional deficit and edema in lung were seen. BDNF was located in cytoplasma of 
      smooth muscle and epithial cells in the lung. The level of BDNF mRNA (indicated 
      by RT-PCR) and the protein level (indicated by ELISA) were all upregulated at 3 
      days after brain ischemia (P<0.05). CONCLUSION: Lung edema occurred after brain 
      ischemia in rats is concomitant with BDNF expression, which consists of the 
      mechanism involved lung injury induced by brain ischemia.
FAU - Dan, Qi-Qin
AU  - Dan QQ
AD  - Translational Neuroscience Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Dai, Ping
AU  - Dai P
FAU - Wang, Sheng-Lan
AU  - Wang SL
FAU - Li, Jin-Tao
AU  - Li JT
FAU - Zhang, Yun-Hui
AU  - Zhang YH
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/complications/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Lung/*metabolism
MH  - Pulmonary Edema/etiology/*metabolism/physiopathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
EDAT- 2013/02/08 06:00
MHDA- 2016/02/03 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;43(6):897-900.