PMID- 23387228
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181202
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 6
DP  - 2012 Nov
TI  - [Effects of BDNF antibody to block IL-1beta expression and lung injury in rats 
      subjected to brain ischemia].
PG  - 918-21
AB  - OBJECTIVE: To explore the effects of brain-derived neurotrophic factor (BDNF) 
      antibody to block lung injury and interleukin-1beta (IL-1beta) expression in the 
      rats with brain ischemia. METHODS: Thirty nine SD rats were divided into sham 
      group, brain ischemia lung injury (BILI) group, and BDNF antibody treated group. 
      Inflammatory lung injury was induced by brain ischemia in the later two groups, 
      and BDNF antibody was given through intraperitoneal injection to the rats for 3 
      days in BDNF antibody group. Lung tissue samples were harvested from the rats in 
      each group at the 3rd day after brain ischemia. Lung edema degree was evaluated 
      by HE staining. The protein expressions of IL-1beta in the lung tissues were 
      measured by the methods of immunohistochemistry (n=5) and Western blot (n=8). 
      RESULTS: The increased immunostaining of IL-1beta were found in the lung tissue 
      at 3 days after brain ischemia, which indicated the upregulated expression of 
      IL-1beta protein in the lung injury induced by cerebral ischemia. The block of 
      BDNF antibody resulted in a significant decrease of IL-1beta expression, as well 
      as the decrease of lung edema. CONCLUSION: BDNF, as a crucial factor, could 
      regulate airway inflammation injury in brain ischemia rats via activating 
      IL-1beta expression.
FAU - Rong, Rong
AU  - Rong R
AD  - Cadre's Ward, Anhui Provincial Hospital, Hefei 230001, China.
FAU - Yang, Ting-Ting
AU  - Yang TT
FAU - Li, Jin-Tao
AU  - Li JT
FAU - Dan, Qi-Qin
AU  - Dan QQ
FAU - Zhang, Yun-Hui
AU  - Zhang YH
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-1beta)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Antibodies/*pharmacology
MH  - Brain Ischemia/complications/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*immunology
MH  - Down-Regulation
MH  - Female
MH  - Interleukin-1beta/genetics/*metabolism
MH  - Lung/*metabolism
MH  - Lung Injury/etiology/*metabolism
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2013/02/08 06:00
MHDA- 2016/02/03 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;43(6):918-21.