PMID- 23387229
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181202
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 6
DP  - 2012 Nov
TI  - [Effects of BDNF antibody block on IL-6 expression in lung of rats subjected to 
      brain ischemia].
PG  - 922-5
AB  - OBJECTIVE: To explore effect of brain-derived neurotrophic factor (BDNF) on IL-6 
      expression in the lung of rats with brain ischemia. METHODS: Inflammatory lung 
      injury was induced by brain ischemia in rats that were devided into sham 
      operation group, brain ischemia lung injury (BILI) group and brain ischemia with 
      BDNF administration group. Lungs were harvested from rats in each group in 3 days 
      after brain ischemia respectively. Immunohistochemistry, RT-PCR and Western blot 
      were employed to detect the expressional changes on the mRNA and protein of IL-6 
      in the lung tissues. RESULTS: Expression of IL-6 was mainly found in cytoplasm of 
      lung epithelial cell and macrophage with immunohistochemistry staining. A 
      significant decrease of IL-6 expression was observed at 3 days after brain 
      ischemia with BDNF antibody block. CONCLUSION: BDNF, as a crucial neurotrophic 
      factor, could regulate IL-6 expression in rats lung tissues with brain ischemia.
FAU - Yang, Yun
AU  - Yang Y
AD  - Department of Respiration, Affiliated Kunhua Hospital of Kunming Science and 
      Technology University, Kunming 650032, China.
FAU - Rong, Rong
AU  - Rong R
FAU - Dan, Qi-Qin
AU  - Dan QQ
FAU - Du, Run-Fen
AU  - Du RF
FAU - Li, Jin-Tao
AU  - Li JT
FAU - Zhang, Yun-Hui
AU  - Zhang YH
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Antibodies/*pharmacology
MH  - Brain Ischemia/complications/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*immunology
MH  - Down-Regulation
MH  - Female
MH  - Interleukin-6/genetics/*metabolism
MH  - Lung/*metabolism
MH  - Lung Injury/etiology/*metabolism
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2013/02/08 06:00
MHDA- 2016/02/03 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Nov;43(6):922-5.