PMID- 23387848
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20151119
IS  - 0289-0003 (Print)
IS  - 0289-0003 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Feb
TI  - The gonadotropin releasing hormone (GnRH)-like molecule in prosobranch Patella 
      caerulea: potential biomarker of endocrine-disrupting compounds in marine 
      environments.
PG  - 135-40
LID - 10.2108/zsj.30.135 [doi]
AB  - It has been reported that endocrine disrupter compounds (EDCs) interfere with the 
      endocrine system, mimicking the action of sex steroid hormones in different 
      species of mollusks. Prosobranchs are frequently used as a reliable bioindicator 
      to evaluate EDC exposure. In this article, we evaluate the effects of the 
      xenoestrogen 4-n-nonylphenol (NP) in the prosobranch gastropod Patella caerulea, 
      which exhibits protandrous hermaphroditism as its reproductive strategy. We 
      isolated a partial sequence of a GnRH-like molecule from the gonads of Patella 
      caerulea. The deduced amino acid sequence is highly homologous to that reported 
      for the Lottia gigantea GnRH. Patella caerulea GnRH (pGnRH) mRNA expression is 
      widespread in both male and female germ lines during gametogenesis. We suggest 
      pGnRH as a novel biomarker for the early assessment of presence of EDCs and 
      monitoring short and long-term impacts on Patella caerulea community structure.
FAU - De Lisa, Emilia
AU  - De Lisa E
AD  - Department of Structural and Functional Biology, University of Napoli "Federico 
      II", via Cinthia, 80126 Napoli, Italy.
FAU - Carella, Francesca
AU  - Carella F
FAU - De Vico, Gionata
AU  - De Vico G
FAU - Di Cosmo, Anna
AU  - Di Cosmo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Zoolog Sci
JT  - Zoological science
JID - 8702287
RN  - 0 (Biomarkers)
RN  - 0 (Endocrine Disruptors)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Biomarkers/*metabolism
MH  - DNA/genetics
MH  - Endocrine Disruptors/*pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Gonads/metabolism
MH  - Mollusca/*drug effects/*metabolism
EDAT- 2013/02/08 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.2108/zsj.30.135 [doi]
PST - ppublish
SO  - Zoolog Sci. 2013 Feb;30(2):135-40. doi: 10.2108/zsj.30.135.