PMID- 23388380
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20211021
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 9
IP  - 4
DP  - 2013 Apr
TI  - DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death.
PG  - 451-8
LID - 10.4161/auto.23691 [doi]
AB  - Autophagy is a lysosome-mediated catabolic process involving the degradation of 
      intracellular contents (e.g., proteins and organelles) as well as invading 
      microbes (e.g., parasites, bacteria and viruses). Multiple forms of cellular 
      stress can stimulate this pathway, including nutritional imbalances, oxygen 
      deprivation, immunological response, genetic defects, chromosomal anomalies and 
      cytotoxic stress. Damage-associated molecular pattern molecules (DAMPs) are 
      released by stressed cells undergoing autophagy or injury, and act as endogenous 
      danger signals to regulate the subsequent inflammatory and immune response. A 
      complex relationship exists between DAMPs and autophagy in cellular adaption to 
      injury and unscheduled cell death. Since both autophagy and DAMPs are important 
      for pathogenesis of human disease, it is crucial to understand how they interplay 
      to sustain homeostasis in stressful or dangerous environments.
FAU - Zhang, Qiuhong
AU  - Zhang Q
AD  - Department of Surgery, University of Pittsburgh Cancer Institute, University of 
      Pittsburgh, Pittsburgh, PA, USA.
FAU - Kang, Rui
AU  - Kang R
FAU - Zeh, Herbert J 3rd
AU  - Zeh HJ 3rd
FAU - Lotze, Michael T
AU  - Lotze MT
FAU - Tang, Daolin
AU  - Tang D
LA  - eng
GR  - R01 CA160417/CA/NCI NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - R01CA160417/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130206
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Animals
MH  - *Autophagy
MH  - Humans
MH  - Lysosomes/metabolism
MH  - Models, Biological
MH  - Receptors, Pattern Recognition/*metabolism
MH  - *Stress, Physiological
PMC - PMC3627663
OTO - NOTNLM
OT  - ATP
OT  - DAMP
OT  - HMGB1
OT  - IL1B
OT  - autophagy
OT  - injury
OT  - stress
EDAT- 2013/02/08 06:00
MHDA- 2013/09/26 06:00
PMCR- 2014/04/01
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 23691 [pii]
AID - 2012AUTO0600R [pii]
AID - 10.4161/auto.23691 [doi]
PST - ppublish
SO  - Autophagy. 2013 Apr;9(4):451-8. doi: 10.4161/auto.23691. Epub 2013 Feb 6.