PMID- 23389889
OWN - NLM
STAT- MEDLINE
DCOM- 20140612
LR  - 20211021
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 4
DP  - 2013 Oct
TI  - Effects of perfusion on diffusion changes in human brain tumors.
PG  - 868-75
LID - 10.1002/jmri.24042 [doi]
AB  - PURPOSE: To characterize the influence of perfusion on the measurement of 
      diffusion changes over time when ADC is computed using standard two-point 
      methods. MATERIALS AND METHODS: Functional diffusion maps (FDMs), which depict 
      changes in diffusion over time, were compared with rCBV changes in patients with 
      brain tumors. The FDMs were created by coregistering and subtracting ADC maps 
      from two time points and categorizing voxels where ADC significantly increased 
      (iADC), decreased (dADC), or did not change (ncADC). Traditional FDMs (tFDMs) 
      were computed using b = 0,1000 s/mm(2). Flow-compensated FDMs (fcFDMs) were 
      calculated using b = 500,1000 s/mm(2). Perfusion's influence on FDMs was 
      determined by evaluating changes in rCBV in areas where the ADC change 
      significantly differed between the two FDMs. RESULTS: The mean DeltarCBV in voxels 
      that changed from iADC (dADC) on the tFDM to ncADC on the fcFDM was significantly 
      greater (less) than zero. In addition, mean DeltarCBV in iADC (dADC) voxels on the 
      tFDM was significantly higher (lower) than in iADC (dADC) voxels on the fcFDM. 
      CONCLUSION: The ability to accurately identify changes in diffusion on 
      traditional FDMs is confounded in areas where perfusion and diffusion changes are 
      colocalized. Flow-compensated FDMs, which use only non-zero b-values, should 
      therefore be the standard approach.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Cohen, Alexander D
AU  - Cohen AD
AD  - Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, 
      USA; Translational Brain Tumor Research Program, Medical College of Wisconsin, 
      Milwaukee, Wisconsin, USA.
FAU - LaViolette, Peter S
AU  - LaViolette PS
FAU - Prah, Melissa
AU  - Prah M
FAU - Connelly, Jennifer
AU  - Connelly J
FAU - Malkin, Mark G
AU  - Malkin MG
FAU - Rand, Scott D
AU  - Rand SD
FAU - Mueller, Wade M
AU  - Mueller WM
FAU - Schmainda, Kathleen M
AU  - Schmainda KM
LA  - eng
GR  - M01 RR000058/RR/NCRR NIH HHS/United States
GR  - 2 R01 CA082500/CA/NCI NIH HHS/United States
GR  - R21 CA109280/CA/NCI NIH HHS/United States
GR  - R01 CA082500/CA/NCI NIH HHS/United States
GR  - UL1 TR000055/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130206
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Algorithms
MH  - Astrocytoma/pathology
MH  - Brain Neoplasms/*pathology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Glioblastoma/*pathology
MH  - Glioma/pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Meningioma/pathology
MH  - Oligodendroglioma/pathology
MH  - *Perfusion
MH  - Reproducibility of Results
MH  - Retrospective Studies
PMC - PMC3735792
MID - NIHMS429441
OTO - NOTNLM
OT  - ADC
OT  - b-value
OT  - brain tumor
OT  - diffusion
OT  - functional diffusion map
OT  - perfusion
EDAT- 2013/02/08 06:00
MHDA- 2014/06/13 06:00
PMCR- 2014/10/01
CRDT- 2013/02/08 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2014/06/13 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 10.1002/jmri.24042 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Oct;38(4):868-75. doi: 10.1002/jmri.24042. Epub 2013 
      Feb 6.