PMID- 23391323
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20211021
IS  - 2050-6511 (Electronic)
IS  - 2050-6511 (Linking)
VI  - 14
DP  - 2013 Feb 8
TI  - Inappropriate long-term use of antipsychotic drugs is common among people with 
      dementia living in specialized care units.
PG  - 10
LID - 10.1186/2050-6511-14-10 [doi]
AB  - BACKGROUND: Antipsychotic drugs are widely used for the treatment of Behavioral 
      and Psychological Symptoms of Dementia (BPSD), despite their limited efficacy and 
      concerns about safety. The aim of this study was to describe antipsychotic drug 
      therapy among people with dementia living in specialized care units in northern 
      Sweden. METHODS: This study was conducted in 40 specialized care units in 
      northern Sweden, with a total study population of 344 people with dementia. The 
      study population was described in regard to antipsychotic drug use, ADL function, 
      cognitive function and BPSD, using the Multi-Dimensional Dementia Assessment 
      Scale (MDDAS). These data were collected at baseline and six months later. 
      Detailed data about antipsychotic prescribing were collected from prescription 
      records. RESULTS: This study showed that 132 persons (38%) in the study 
      population used antipsychotic drugs at the start of the study. Of these, 52/132 
      (39%) had prescriptions that followed national guidelines with regard to dose and 
      substance.After six months, there were 111 of 132 persons left because of deaths 
      and dropouts. Of these 111 people, 80 (72%) were still being treated with 
      antipsychotics, 63/111 (57%) with the same dose. People who exhibited aggressive 
      behavior (OR: 1.980, CI: 1.515-2.588), or passiveness (OR: 1.548, CI: 
      1.150-2.083), or had mild cognitive impairment (OR: 2.284 CI: 1.046-4.988), were 
      at increased risk of being prescribed antipsychotics. CONCLUSION: The prevalence 
      of antipsychotic drug use among people with dementia living in specialized care 
      units was high and inappropriate long-term use of antipsychotic drugs was common.
FAU - Gustafsson, Maria
AU  - Gustafsson M
AD  - Maria Gustafsson, Department of Pharmacology and Clinical Neuroscience, Umea 
      University, 901 85, Umea, Sweden. maria.gustafsson@pharm.umu.se
FAU - Karlsson, Stig
AU  - Karlsson S
FAU - Lovheim, Hugo
AU  - Lovheim H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130208
PL  - England
TA  - BMC Pharmacol Toxicol
JT  - BMC pharmacology & toxicology
JID - 101590449
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*therapeutic use
MH  - Dementia/*drug therapy
MH  - Drug Utilization Review/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Homes/statistics & numerical data
MH  - Sweden
PMC - PMC3575309
EDAT- 2013/02/09 06:00
MHDA- 2013/07/10 06:00
PMCR- 2013/02/08
CRDT- 2013/02/09 06:00
PHST- 2012/09/17 00:00 [received]
PHST- 2013/02/04 00:00 [accepted]
PHST- 2013/02/09 06:00 [entrez]
PHST- 2013/02/09 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
PHST- 2013/02/08 00:00 [pmc-release]
AID - 2050-6511-14-10 [pii]
AID - 10.1186/2050-6511-14-10 [doi]
PST - epublish
SO  - BMC Pharmacol Toxicol. 2013 Feb 8;14:10. doi: 10.1186/2050-6511-14-10.