PMID- 23392983 OWN - NLM STAT- MEDLINE DCOM- 20140312 LR - 20211021 IS - 1432-2218 (Electronic) IS - 0930-2794 (Linking) VI - 27 IP - 8 DP - 2013 Aug TI - Is the transvaginal route appropriate for intra-abdominal NOTES procedures? Experience and follow-up of 222 cases. PG - 2807-12 LID - 10.1007/s00464-013-2812-z [doi] AB - BACKGROUND: Since 2007, natural orifice transluminal endoscopic surgery (NOTES) has been applied in humans. We performed this prospective study to evaluate the transvaginal route in terms of risks, complication rate, and long-term side effects such as dyspareunia. METHODS: From June 2007 to September 2011, we performed 222 transvaginal hybrid NOTES procedures: 220 transvaginal cholecystectomies (TVC) and 2 transvaginal appendectomies (TVA). All patients were asked to present to our associated gynecologists within 1 week for an examination. After at least 3 months, the patients were interviewed using a standard questionnaire. RESULTS: All operations could be successfully performed in this technique except two cases, which were converted to conventional laparoscopic cholecystectomy. The only intraoperative complication was the puncture of the urine bladder. We observed two postoperative complications: one biliary fistula 3 days after TVC, and one abscess in the Douglas pouch 3 weeks after TVC. The gynecological examinations revealed no abnormalities. The interview (median postoperative time, 6 months) with a follow-up rate of 93 % revealed no pain in the pelvis, dyspareunia, or sexual dysfunction after TVC. CONCLUSIONS: The transvaginal route is appropriate for NOTES procedures; there is only a minor and acceptable rate of intra- and postoperative morbidity. FAU - Mofid, Hamid AU - Mofid H AD - Department of Surgery, Israelitisches Krankenhaus, Orchideenstieg 14, 22297 Hamburg, Germany. hamid@mofid.de FAU - Emmermann, Alice AU - Emmermann A FAU - Alm, Margret AU - Alm M FAU - von Waldenfels, Hans-Albrecht AU - von Waldenfels HA FAU - Felixmuller, Conrad AU - Felixmuller C FAU - Zornig, Carsten AU - Zornig C LA - eng PT - Comparative Study PT - Journal Article DEP - 20130208 PL - Germany TA - Surg Endosc JT - Surgical endoscopy JID - 8806653 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Appendectomy/*methods MH - Cholecystectomy/*methods MH - Dyspareunia/*epidemiology/etiology MH - Female MH - Follow-Up Studies MH - Germany/epidemiology MH - Humans MH - Middle Aged MH - Natural Orifice Endoscopic Surgery/*methods MH - Postoperative Complications/epidemiology/etiology MH - Prospective Studies MH - Risk Factors MH - Surveys and Questionnaires MH - Time Factors MH - Treatment Outcome MH - Vagina MH - Young Adult EDAT- 2013/02/09 06:00 MHDA- 2014/03/13 06:00 CRDT- 2013/02/09 06:00 PHST- 2012/10/30 00:00 [received] PHST- 2012/12/31 00:00 [accepted] PHST- 2013/02/09 06:00 [entrez] PHST- 2013/02/09 06:00 [pubmed] PHST- 2014/03/13 06:00 [medline] AID - 10.1007/s00464-013-2812-z [doi] PST - ppublish SO - Surg Endosc. 2013 Aug;27(8):2807-12. doi: 10.1007/s00464-013-2812-z. Epub 2013 Feb 8.