PMID- 23394103
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20220318
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 35
IP  - 3
DP  - 2013
TI  - Is there association between uric acid and inflammation in hemodialysis patients?
PG  - 361-6
LID - 10.3109/0886022X.2013.764274 [doi]
AB  - BACKGROUND: Elevated serum uric acid has been associated with a variety of 
      cardiovascular disease and with inflammation, but these have been little explored 
      in chronic kidney disease (CKD). Elevated uric acid levels are common in CKD 
      patients and could be involved in inflammatory milieu; our aim was to analyze the 
      association between uric acid and inflammatory markers in hemodialysis (HD) 
      patients. DESIGN: This was a cross-sectional study. SETTING: This study was 
      conducted from private clinic, Rio de Janeiro, Brazil. PATIENTS: This study 
      included 50 HD patients and 21 healthy subjects. METHODS AND PROCEDURES: This 
      study included 50 HD patients [62% men, 54.3 +/- 12.6 years, 57.5 +/- 50.1 months on 
      dialysis, and body mass index (BMI), 24.4 +/- 4.1 kg/m2] and 21 healthy individuals 
      (45% men, 50.7 +/- 15.7 years and BMI, 25.5 +/- 4 kg/m2). Uric acid was measured 
      using uricase-PAP method; inflammatory [tumor necrosis factor-alpha (TNF-alpha), 
      interleukin-6 (IL-6), C-reactive protein (CRP)] and atherosclerosis markers 
      [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 
      (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), plasminogen activator 
      inhibitor-1 (PAI-1)] were measured by a multiplexed assay. RESULTS: PATIENTS 
      presented high levels of TNF-alpha, IL-6, CRP, VCAM-1, ICAM-1 (5.5 +/- 2.1 pg/mL, 4.1 +/- 
      1.6 pg/mL, 0.32 +/- 0.30 mg/mL, 48.5 +/- 8.5 ng/mL, 20.5 +/- 15.9 ng/mL, respectively), 
      compared with healthy individuals (2.4 +/- 1.1 pg/mL, 2.7 +/- 0.4 pg/mL, 0.11 +/- 0.12 
      mg/mL, 23.8 +/- 5.5 ng/mL, 7.2 +/- 1.2 ng/mL, respectively) ( p < 0.04). Uric acid 
      levels were also higher in HD patients (5.4 +/- 1.3 mg/dL) than in healthy 
      individuals (3.9 +/- 0.9 mg/dL) ( p < 0.02). There was a positive correlation 
      between uric acid and inflammatory markers, IL-6 (r = 0.30, p = 0.01), CRP (r = 
      0.37, p = 0.003), TNF-alpha (r = 0.40, p = 0.001), ICAM-1 (r = 0.53, p = 0.0001), and 
      VCAM-1 (r = 0.45, p = 0.0001). CONCLUSION: These original data suggest that uric 
      acid may have a role in inflammation and atherosclerosis in HD patients. However, 
      further prospective studies involving intervention trials should be conducted in 
      order to search for actual causality relationship between these markers.
FAU - Lobo, Julie Calixto
AU  - Lobo JC
AD  - Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niteroi, 
      Rio de Janeiro, Brazil.
FAU - Stockler-Pinto, Milena Barcza
AU  - Stockler-Pinto MB
FAU - da Nobrega, Antonio Claudio Lucas
AU  - da Nobrega AC
FAU - Carraro-Eduardo, Jose Carlos
AU  - Carraro-Eduardo JC
FAU - Mafra, Denise
AU  - Mafra D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130211
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Kidney Failure, Chronic/*blood
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Renal Dialysis
MH  - Uric Acid/*blood
EDAT- 2013/02/12 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.3109/0886022X.2013.764274 [doi]
PST - ppublish
SO  - Ren Fail. 2013;35(3):361-6. doi: 10.3109/0886022X.2013.764274. Epub 2013 Feb 11.