PMID- 23394402
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20131121
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 29
IP  - 9
DP  - 2013 Mar 5
TI  - Surface structures of PDMS incorporated with quaternary ammonium salts designed 
      for antibiofouling and fouling release applications.
PG  - 2897-905
LID - 10.1021/la304571u [doi]
AB  - Poly(dimethylsiloxane) (PDMS) materials have been extensively shown to function 
      as excellent fouling-release (FR) coatings in the marine environment. The 
      incorporation of biocide moieties, such as quaternary ammonium salts (QAS), can 
      impart additional antibiofouling properties to PDMS-based FR coating systems. In 
      this study, the molecular surface structures of two different types of 
      QAS-incorporated PDMS systems were investigated in different chemical 
      environments using sum frequency generation vibrational spectroscopy (SFG). 
      Specifically, a series of PDMS coatings containing either a QAS with a single 
      ammonium salt group per molecule or a quaternary ammonium-functionalized 
      polyhedral oligomeric silsesquioxane (Q-POSS) were measured with SFG in air, 
      water, and artificial seawater (ASW) to investigate the relationships between the 
      interfacial surface structures of these materials and their antifouling 
      properties. Although previous studies have shown that the above-mentioned 
      materials are promising contact-active antifouling coatings, slight variations of 
      the QAS structure can lead to substantial differences in the antifouling 
      performance. Indeed, the SFG results presented here indicated that the surface 
      structures of these materials depend on several factors, such as the extent of 
      quaternization, the molecular weight of the PDMS component, and the functional 
      groups of the QAS used for incorporation into the PDMS matrix. It was concluded 
      that in aqueous environments a lower extent of Q-POSS quaternization and the use 
      of ethoxy (instead of methoxy) functional groups for QAS incorporation 
      facilitated the extension of the alkyl chains away from the nitrogen atom of the 
      QAS on the surface. The SFG results correlated well with the antifouling activity 
      studies that indicated that the coatings exhibiting a lower concentration of 
      longer alkyl chains protruding out of the surface can neutralize microorganisms 
      more effectively, ultimately leading to better antifouling performance. 
      Furthermore, the results of this study provide additional evidence that 
      incorporated QAS exert their antimicrobial activity through a two-step 
      interaction. The first step is the adsorption of the bacteria on the surface as a 
      result of the electrostatic attraction between the negatively charged 
      microorganisms and the positively charged QAS nitrogen atoms on the surface. The 
      second step is the disruption of the cell membranes by the penetration of the QAS 
      long, extended alkyl chains.
FAU - Liu, Yuwei
AU  - Liu Y
AD  - Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
FAU - Leng, Chuan
AU  - Leng C
FAU - Chisholm, Bret
AU  - Chisholm B
FAU - Stafslien, Shane
AU  - Stafslien S
FAU - Majumdar, Partha
AU  - Majumdar P
FAU - Chen, Zhan
AU  - Chen Z
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130225
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Salts)
RN  - 0 (Silanes)
RN  - 059QF0KO0R (Water)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Air
MH  - Anti-Infective Agents/chemistry/pharmacology
MH  - Biofouling/*prevention & control
MH  - Dimethylpolysiloxanes/*chemistry/*pharmacology
MH  - *Drug Design
MH  - Quaternary Ammonium Compounds/*chemistry
MH  - Salts/*chemistry
MH  - Silanes/chemistry
MH  - Structure-Activity Relationship
MH  - Surface Properties
MH  - Water/chemistry
EDAT- 2013/02/12 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1021/la304571u [doi]
PST - ppublish
SO  - Langmuir. 2013 Mar 5;29(9):2897-905. doi: 10.1021/la304571u. Epub 2013 Feb 25.