PMID- 23394906
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20220317
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 155
IP  - 5
DP  - 2013 May
TI  - Characterization of microaneurysm closure after focal laser photocoagulation in 
      diabetic macular edema.
PG  - 905-12
LID - S0002-9394(12)00859-8 [pii]
LID - 10.1016/j.ajo.2012.12.005 [doi]
AB  - PURPOSE: To characterize microaneurysm closure following focal laser 
      photocoagulation in diabetic macular edema (DME) using simultaneous fluorescein 
      angiography (FA) and spectral-domain optical coherence tomography (SD-OCT). 
      DESIGN: Retrospective observational case series. METHODS: Leaking microaneurysms 
      (n = 123) were analyzed in eyes (n = 29) with nonproliferative diabetic 
      retinopathy (NPDR) that underwent navigated focal laser photocoagulation in DME 
      and were followed at 3, 6, and 12 months. Closure of diabetic microaneurysms was 
      characterized in detail following focal laser using SD-OCT. RESULTS: Closure rate 
      of microaneurysms by both FA and SD-OCT was 69.9% (84/123), 79.7% (98/123), and 
      82.9% (102/123) at 3, 6, and 12 months, respectively. Microaneurysm closure rate 
      increased at 6 and 12 months compared to 3 months (P < .003, P < .001). Over half 
      of closed microaneurysms (45/86, 52.3%) left hyperreflective spots while the 
      remaining half (41/86, 47.7%) disappeared without any hyperreflectivity by SD-OCT 
      at 3 months. Hyperreflective spots decreased at 6 (36/99, 36.4%) and 12 months 
      (17/102, 16.7%) with a concomitant increase in complete loss of reflectivity at 6 
      (63/99, 63.6%) and 12 months (85/102, 83.3%). Smaller outer and inner diameters 
      and heterogeneous lumen reflectivity were positively associated with 
      microaneurysm closure at 12 months (P < .0001, P < .001, P < .03). CONCLUSIONS: 
      Characterization of microaneurysms following focal laser photocoagulation 
      resulted in hyperreflective spots and complete resolution of all reflectivity 
      using SD-OCT. Smaller microaneurysms and those with heterogeneous lumen were 
      positively associated with microaneurysm closure. These findings provide greater 
      understanding of localized retinal changes following focal laser photocoagulation 
      in DME treatment.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lee, Su Na
AU  - Lee SN
AD  - Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, 
      University of California San Diego, La Jolla, CA 92037, USA.
FAU - Chhablani, Jay
AU  - Chhablani J
FAU - Chan, Candy K
AU  - Chan CK
FAU - Wang, Haiyan
AU  - Wang H
FAU - Barteselli, Giulio
AU  - Barteselli G
FAU - El-Emam, Sharif
AU  - El-Emam S
FAU - Gomez, Maria L
AU  - Gomez ML
FAU - Kozak, Igor
AU  - Kozak I
FAU - Cheng, Lingyun
AU  - Cheng L
FAU - Freeman, William R
AU  - Freeman WR
LA  - eng
GR  - R01EY020617/EY/NEI NIH HHS/United States
GR  - R01 EY018589/EY/NEI NIH HHS/United States
GR  - R01EY018589/EY/NEI NIH HHS/United States
GR  - R01EY007366/EY/NEI NIH HHS/United States
GR  - R01 EY007366/EY/NEI NIH HHS/United States
GR  - R01 EY020617/EY/NEI NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130206
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aneurysm/complications/*diagnosis/surgery
MH  - Diabetic Retinopathy/complications/diagnosis/*surgery
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - *Laser Coagulation
MH  - Macular Edema/diagnosis/etiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology
MH  - *Retinal Artery
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
PMC - PMC3627831
MID - NIHMS443911
EDAT- 2013/02/12 06:00
MHDA- 2013/06/05 06:00
PMCR- 2014/05/01
CRDT- 2013/02/12 06:00
PHST- 2012/08/10 00:00 [received]
PHST- 2012/11/30 00:00 [revised]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S0002-9394(12)00859-8 [pii]
AID - 10.1016/j.ajo.2012.12.005 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 May;155(5):905-12. doi: 10.1016/j.ajo.2012.12.005. Epub 
      2013 Feb 6.