PMID- 23395913
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20141013
IS  - 1879-0720 (Electronic)
IS  - 0928-0987 (Linking)
VI  - 49
IP  - 1
DP  - 2013 Apr 11
TI  - Warning against co-administration of 3,4-methylenedioxymethamphetamine (MDMA) 
      with methamphetamine from the perspective of pharmacokinetic and pharmacodynamic 
      evaluations in rat brain.
PG  - 57-64
LID - S0928-0987(13)00055-9 [pii]
LID - 10.1016/j.ejps.2013.01.014 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine often cause serious 
      adverse effects (e.g., rhabdomyolysis, and cardiac disease) following 
      hyperthermia triggered by release of brain monoamines such as dopamine and 
      serotonin. Therefore, evaluation of brain monoamine concentrations is useful to 
      predict these drugs' risks in human. This study aimed to evaluate risks of 
      co-administration of MDMA and methamphetamine, both of which are abused 
      frequently in Japan, based on drug distribution and monoamine level in the rat 
      brain. Rats were allocated to three groups: (1) sole MDMA administration (12 or 
      25 mg/kg, intraperitoneally), (2) sole methamphetamine administration (10 mg/kg, 
      intraperitoneally) and (3) co-administration of MDMA (12 mg/kg, 
      intraperitoneally) and methamphetamine (10 mg/kg, intraperitoneally). We 
      monitored pharmacokinetic and pharmacodynamic variables for drugs and monoamines 
      in the rat brain. Area under the curve for concentration vs. time until 600 min 
      from drug administration (AUC(0)(-)(6)(0)(0)) increased from 348.0 to 689.8 mugmin/L for 
      MDMA and from 29.9 to 243.4 muMmin for dopamine in response to co-administration 
      of methamphetamine and MDMA compared to sole MDMA (12 mg/kg) administration. 
      After sole methamphetamine or that with MDMA administration, AUC(0)(-)(6)(0)(0) of 
      methamphetamine were 401.8 and 671.1 mugmin/L, and AUC(0)(-)(6)(0)(0) of dopamine were 159.9 
      and 243.4 muMmin. In conclusion, the brain had greater exposure to MDMA, 
      methamphetamine and dopamine after co-administration of MDMA and methamphetamine 
      than when these two drugs were given alone. This suggests co-administration of 
      MDMA with methamphetamine confers greater risk than sole administration, and that 
      adverse events of MDMA ingestion may increase when methamphetamine is 
      co-administered.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Yuki, Fuchigami
AU  - Yuki F
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan. Electronic address: bb55712002@cc.nagasaki-u.ac.jp.
FAU - Rie, Ikeda
AU  - Rie I
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan. Electronic address: r-ikeda@nagasaki-u.ac.jp.
FAU - Miki, Kuzushima
AU  - Miki K
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan.
FAU - Mitsuhiro, Wada
AU  - Mitsuhiro W
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan. Electronic address: m-wada@nagasaki-u.ac.jp.
FAU - Naotaka, Kuroda
AU  - Naotaka K
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan.
FAU - Kenichiro, Nakashima
AU  - Kenichiro N
AD  - Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, 
      Nagasaki 852-8131, Japan; Faculty of Pharmaceutical Sciences, Nagasaki 
      International University, 2825-7 Huis Ten Bosch Sasebo, Nagasaki 859-3298, Japan.
LA  - eng
PT  - Journal Article
DEP - 20130208
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European 
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Methamphetamine/*administration & dosage/adverse effects/*pharmacokinetics
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/adverse 
      effects/*pharmacokinetics
MH  - Rats
MH  - Rats, Wistar
EDAT- 2013/02/12 06:00
MHDA- 2015/09/15 06:00
CRDT- 2013/02/12 06:00
PHST- 2012/11/05 00:00 [received]
PHST- 2013/01/18 00:00 [revised]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0928-0987(13)00055-9 [pii]
AID - 10.1016/j.ejps.2013.01.014 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2013 Apr 11;49(1):57-64. doi: 10.1016/j.ejps.2013.01.014. Epub 
      2013 Feb 8.