PMID- 23396275
OWN - NLM
STAT- MEDLINE
DCOM- 20140128
LR  - 20191112
VI  - 123
IP  - 3
DP  - 2013
TI  - Menopausal hormone therapy for the primary prevention of chronic conditions. U.S. 
      Preventive Services Task Force recommendation statement.
PG  - 112-7
LID - AOP_13_009 [pii]
AB  - Since the early 20th century, scientists have been tantalized with the hypothesis 
      that premenopausal health benefits in women can be preserved in postmenopausal 
      women with the supplementation of exogenous hormone replacement therapy (HRT) of 
      estrogen (alone/with progesterone). This hypothesis was shattered when the 
      results of 2 large randomized controlled trials (RCTs), the Heart 
      Estrogen/Progesterone Replacement Study (HERS) and Women's Health Initiative 
      (WHI), reported an increased risk of adverse clinical outcomes including coronary 
      heart disease, thromboembolic events, stroke, dementia, urinary incontinence, 
      gallbladder disease, and breast cancer. However, since the WHI was published, 
      firestorms of critique, controversy, and multiple subgroup analyses have 
      populated the medical literature, predominantly focused around the analysis of 
      the age of women at entry into the trials (hypothesized as an effect modifier) 
      and suggesting lower-dose preparations including using bioidentical hormones. 
      Recently, the U.S. Preventive Services Task Force (USPSTF) along with other 
      professional groups have issued recommendations against the use of HRT to prevent 
      chronic conditions. In this review, we review the most recent evidence, including 
      the long-term follow-up data from RCTs along a multitude of health outcomes.
FAU - Kreatsoulas, Catherine
AU  - Kreatsoulas C
AD  - Department of Social and Behavioral Sciences, Human Development and Health, 
      Harvard School of Public Health, Harvard University, Boston, MA 02138, USA. 
      ckreats@hsph.harvard.edu
FAU - Anand, Sonia S
AU  - Anand SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130211
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/prevention & control
MH  - Cardiovascular Diseases/prevention & control
MH  - Chronic Disease/*prevention & control
MH  - Estrogen Replacement Therapy/adverse effects/*statistics & numerical data
MH  - Female
MH  - Fractures, Bone/prevention & control
MH  - Gallbladder Diseases/prevention & control
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Menopause
MH  - Middle Aged
MH  - Primary Prevention/*methods/*standards
MH  - Randomized Controlled Trials as Topic
MH  - United States
MH  - Urinary Incontinence/prevention & control
MH  - Women's Health
EDAT- 2013/02/12 06:00
MHDA- 2014/01/29 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2014/01/29 06:00 [medline]
AID - AOP_13_009 [pii]
AID - 10.20452/pamw.1625 [doi]
PST - ppublish
SO  - Pol Arch Med Wewn. 2013;123(3):112-7. doi: 10.20452/pamw.1625. Epub 2013 Feb 11.