PMID- 23397081
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20211021
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 30
IP  - 1
DP  - 2013 Mar
TI  - Expression and clinical significance of SIAH in laryngeal squamous cell 
      carcinoma.
PG  - 485
LID - 10.1007/s12032-013-0485-z [doi]
AB  - SIAH is widely expressed in lot of kinds of tumors. It plays a significant role 
      in human cancer, but its clinicopathologic and prognostic significance in 
      laryngeal squamous cell carcinoma (LSCC) has not yet been elucidated. The SIAH 
      expression was examined at mRNA and protein levels by real-time quantitative 
      polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry in 
      LSCC tissues and adjacent normal larynx tissues. Statistical analyses were 
      applied to test the associations between SIAH expression, clinicopathologic 
      factors, and prognosis. Western blots and RT-PCR showed that the expression level 
      of SIAH was lower in LSCC tissues than in adjacent normal larynx tissues. By 
      immunohistochemical analysis, reduced expression of SIAH was found in 71.67 % 
      LSCCs. After multivariate analysis, along with pathologic differentiation, the 
      protein expression level of SIAH was an independent and significant predictive 
      factor (P = 0.04). Furthermore, patients with SIAH-low tumors had a shorter 
      disease-free survival and overall survival (P = 0.002 and P = 0.045, 
      respectively). Our study suggests that SIAH protein expression is a valuable 
      biomarker for LSCC. Low expression of SIAH is associated with poor disease-free 
      survival and overall survival in LSCC patients.
FAU - Liu, Xue-Kui
AU  - Liu XK
AD  - State Key Laboratory of Oncology in South China, Department of Head and Neck 
      Surgery, Sun Yat-Sen University Cancer Centre, Guangzhou, Guangdong, China.
FAU - Li, Quan
AU  - Li Q
FAU - Xu, Li-Hua
AU  - Xu LH
FAU - Hu, Li-Juan
AU  - Hu LJ
FAU - Liao, Wei-Guo
AU  - Liao WG
FAU - Zhang, Xin-Rui
AU  - Zhang XR
FAU - Liu, Zhi-Min
AU  - Liu ZM
FAU - Wu, Di
AU  - Wu D
FAU - Zeng, Mu-Sheng
AU  - Zeng MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130209
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (Nuclear Proteins)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.3.2.27 (seven in absentia proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/mortality/*pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*genetics/metabolism
MH  - Reference Values
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ubiquitin-Protein Ligases/*genetics/metabolism
MH  - Uterine Cervical Neoplasms/genetics/pathology/secondary
EDAT- 2013/02/12 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/02/12 06:00
PHST- 2012/12/26 00:00 [received]
PHST- 2013/01/28 00:00 [accepted]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - 10.1007/s12032-013-0485-z [doi]
PST - ppublish
SO  - Med Oncol. 2013 Mar;30(1):485. doi: 10.1007/s12032-013-0485-z. Epub 2013 Feb 9.