PMID- 23397209
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20211021
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 97
IP  - 3
DP  - 2013 Mar
TI  - Inclusion of hemoglobin level in prognostic score provides better prognostic 
      stratification in patients with acute promyelocytic leukemia (APL).
PG  - 388-96
LID - 10.1007/s12185-013-1276-1 [doi]
AB  - The clinical outcomes of acute promyelocytic leukemia (APL) have improved 
      greatly, but treatment failure still occurs. Identification of patients with poor 
      prognosis is fundamental, and we propose a new clinical prognostic system 
      (CBC-score) consisting of WBC, platelet count, and hemoglobin level. Between 1995 
      and 2009, 156 patients with APL from seven institutes in Korea were 
      retrospectively reviewed. In the new CBC-score system, each of the following (WBC 
      >/= 10 x 109/L, platelet <40 x 109/L, hemoglobin <8.0 g/dL) was considered as a 
      risk factor; the sum of each was designated as the CBC-score. With a median 
      follow-up of 8.4 years, the complete remission (CR) rate was 81.4 % (127/156), 
      while 24 (15.4 %) were considered as treatment failures due to early death (ED). 
      The 5-year overall survival (OS), leukemia-free survival, and cumulative 
      incidence of relapse were 73.8, 82.8, and 13.5 %, respectively. Compared to the 
      individual CBC parameters, combined prognostic systems such as PETHEMA or 
      CBC-score provided better prognostic stratification. Compared to PETHEMA 
      stratification, the proposed prognostic CBC-score system showed better 
      stratification of APL patients in terms of CR rates (p = 0.004), OS (p = 0.004), 
      and ED (p = 0.008). This retrospective study suggests that the proposed CBC-score 
      may provide better prognostic stratification of APL patients.
FAU - Park, Silvia
AU  - Park S
AD  - Division of Hematology-Oncology, Department of Medicine, Samsung Meidical Center, 
      Sungkyunkwan University School of Medicine, 50, Irwon-dong, Gangnam-gu, Seoul, 
      135-710, Korea.
FAU - Lee, Su Jin
AU  - Lee SJ
FAU - Kim, Kihyun
AU  - Kim K
FAU - Jang, Jun Ho
AU  - Jang JH
FAU - Kim, Dong Hwan
AU  - Kim DH
FAU - Lee, Kyu Hyung
AU  - Lee KH
FAU - Lee, Je Hwan
AU  - Lee JH
FAU - Lee, Jung Hee
AU  - Lee JH
FAU - Kim, Dae Young
AU  - Kim DY
FAU - Jang, Dae-Young
AU  - Jang DY
FAU - Kim, Hawk
AU  - Kim H
FAU - Park, Jae Hoo
AU  - Park JH
FAU - Ryoo, Hun Mo
AU  - Ryoo HM
FAU - Bae, Sung Hwa
AU  - Bae SH
FAU - Kim, Min Kyung
AU  - Kim MK
FAU - Hyun, Myung Soo
AU  - Hyun MS
FAU - Joo, Young Don
AU  - Joo YD
FAU - Lee, Won Sik
AU  - Lee WS
FAU - Lee, Sang Min
AU  - Lee SM
FAU - Jung, Chul Won
AU  - Jung CW
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130209
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Hemoglobins)
SB  - IM
CIN - Int J Hematol. 2014 Jan;99(1):100-1. PMID: 24037456
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Hemoglobins/analysis/*metabolism
MH  - Humans
MH  - Leukemia, Promyelocytic, Acute/*blood/*mortality/therapy
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2013/02/12 06:00
MHDA- 2013/11/16 06:00
CRDT- 2013/02/12 06:00
PHST- 2012/11/08 00:00 [received]
PHST- 2013/01/16 00:00 [accepted]
PHST- 2013/01/16 00:00 [revised]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
AID - 10.1007/s12185-013-1276-1 [doi]
PST - ppublish
SO  - Int J Hematol. 2013 Mar;97(3):388-96. doi: 10.1007/s12185-013-1276-1. Epub 2013 
      Feb 9.